{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T15:29:21Z","timestamp":1750346961763,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to evaluate chemical stability and physical compatibility when combining fentanyl, rocuronium, and atropine in a fixed ratio to support intramuscular drug delivery during fetal intervention and surgery. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A highly concentrated combination of fentanyl, rocuronium, and atropine was created based on common prescribing practices at a maternal-fetal care center. Chemical stability testing was completed using liquid chromatograph mass spectrometry-mass spectrometry (LC\/MS-MS) to detect and quantitate atropine, rocuronium, and fentanyl, with fentanyl-d&lt;sub&gt;5&lt;\/sub&gt; being an internal standard at 6, 12, 24, and 36 h following sample preparation. Physical compatibility testing was completed using United States Pharmacopeia (USP) &amp;lt;788&amp;gt; recommended analytical technique of light obscuration in addition to novel backgrounded membrane imaging at 6 and 24 h following sample preparation. Physical compatibility was determined using USP &amp;lt;788&amp;gt; particle count limits for both techniques. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Based on LC\/MS-MS results, the samples retained expected medication concentrations at all time points tested. For physical compatibility testing, the particle counts met criteria to be considered compatible per USP &amp;lt;788&amp;gt; large-volume particle count thresholds at 6 h by both methods but exceeded tolerable thresholds at 24 h. &lt;b&gt;&lt;i&gt;Discussion\/Conclusion:&lt;\/i&gt;&lt;\/b&gt; The combination of rocuronium, fentanyl, and atropine for intramuscular fetal administration is physically compatible and chemically stable for 6 h. <\/jats:p>","DOI":"10.1159\/000538611","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T21:00:31Z","timestamp":1714683631000},"page":"313-319","source":"Crossref","is-referenced-by-count":1,"title":["Stability and Compatibility of an Intramuscular Fetal Anesthetic Cocktail for Fetal Intervention"],"prefix":"10.1159","volume":"51","author":[{"given":"Emma L.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina L.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Wempe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2021.06.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2021.10.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005177"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2019.04.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000047085"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200110000-00008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-28.1.84"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2469"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/4\/313\/4264303\/000538611.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/4\/313\/4264303\/000538611.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:14:24Z","timestamp":1745421264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,9]]},"published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000538611","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2024]]}}}