{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:39:18Z","timestamp":1769200758762,"version":"3.49.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Heart failure (HF) is difficult to diagnose in obese patients because of cardiovascular and pulmonary comorbidities associated with physical deconditioning, all of which lead to dyspnea. <b><i>Methods:<\/i><\/b> The OLECOEUR study is a prospective screening for HF using systematic brain natriuretic peptide (BNP) measurement in ambulatory patients with obesity from a department of Nutrition (Paris, France). Clinical, biological, and echocardiographic data were extracted from electronic medical records. <b><i>Results:<\/i><\/b> We included 1,506 patients middle-aged (mean age: 47.2 \u00b1 14.6 years old) with severe obesity (mean body mass index: 40.4 \u00b1 6.6 kg\/m<sup>2<\/sup>). Patients with BNP \u226535 pg\/mL had left heart remodeling including thicker interventricular septum (10.4 \u00b1 2.0 vs. 9.6 \u00b1 1.8 mm; <i>p<\/i> = 0.0008), higher left ventricular mass (89.9 \u00b1 24.3 vs. 77.2 \u00b1 20.0 g\/m<sup>2<\/sup>; <i>p<\/i> = 0.0009), and significant changes in both left and right atria consistent with a higher proportion of prior atrial fibrillation. Markers of right heart remodeling on echocardiography were also significantly higher (pulmonary artery systolic pressure: 33.3 \u00b1 17.3 vs. 24.5 \u00b1 6.3 mm Hg; <i>p<\/i> = 0.0002). <b><i>Conclusion:<\/i><\/b> The OLECOEUR study shows left and right subclinical cardiac remodeling in obese patients screened for HF with systematic dosing of BNP with usual cut-off of 35 pg\/mL. <\/jats:p>","DOI":"10.1159\/000538766","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T21:00:30Z","timestamp":1716498030000},"page":"296-302","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Brain Natriuretic Peptide Measurement for Cardiac Screening in Patients with Severe Obesity: The OLECOEUR Study"],"prefix":"10.1159","volume":"17","author":[{"given":"Claire","family":"Carette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Okamba-Belle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Hirlemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Wack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orianne","family":"Domenge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Jannot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Czernichow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Rives-Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Fayol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-S\u00e9bastien","family":"Hulot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31071-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020245"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101266"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1858"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13717"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93432-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2021.12.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4158\/EP161365.GL"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2021.05.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030744"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2017.02.006"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ofa\/article-pdf\/17\/3\/296\/4237445\/000538766.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ofa\/article-pdf\/17\/3\/296\/4237445\/000538766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:15:34Z","timestamp":1745421334000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000538766","archive":["Portico"],"relation":{},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}