{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:47:58Z","timestamp":1786362478568,"version":"build-2736575974"},"reference-count":31,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"abstract":"<b><i>Introduction:<\/i><\/b> This study aimed to evaluate the association between the NephroCheck<sup>\u00ae<\/sup> test AKIRisk<sup>\u00ae<\/sup> score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). <b><i>Methods:<\/i><\/b> The study prospectively enrolled 125 patients admitted with AHF. NephroCheck<sup>\u00ae<\/sup> test was obtained within the first 24 h of admission. DE was defined as net fluid urine output per 40 mg of furosemide equivalents. <b><i>Results:<\/i><\/b> The median AKIRisk<sup>\u00ae<\/sup> score was 0.11 (IQR 0.06\u20130.34), and 38 (30.4%) patients had an AKIRisk<sup>\u00ae<\/sup> score &gt;0.3. The median cumulative DE at 72 h was 1,963 mL (IQR 1317\u20133,239 mL). At 72 h, a total of 10 (8%) patients developed an absolute increase in sCr \u22650.5 mg\/dL (WKF). In a multivariable setting, there was an inverse association between the AKIRisk<sup>\u00ae<\/sup> score and DE within the first 72 h. In fact, the highest the AKIRisk<sup>\u00ae<\/sup> score (centered at 0.3), the higher the likelihood of poor DE (below the median) and WKF at 72 h (odds ratio [OR] 2.04; 95%; CI: 1.02\u20134.07; <i>p<\/i> = 0.043, and OR 3.31, 95% CI: 1.30\u20138.43; <i>p<\/i> = 0.012, respectively). <b><i>Conclusion:<\/i><\/b> In patients with AHF, a higher NephroCheck<sup>\u00ae<\/sup> AKIRisk<sup>\u00ae<\/sup> score is associated with poorer DE and a higher risk of WKF at 72 h. Further research is needed to confirm the role of urinary cell cycle arrest biomarkers in the AHF scenario. <\/jats:p>","DOI":"10.1159\/000538774","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T21:00:34Z","timestamp":1713387634000},"page":"1-1","source":"Crossref","is-referenced-by-count":2,"title":["Urinary Cell Cycle Arrest Biomarkers and Diuretic Efficiency in Acute Heart Failure"],"prefix":"10.1159","author":[{"given":"Gonzalo","family":"N\u00fa\u00f1ez-Mar\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Romero-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-9051","authenticated-orcid":false,"given":"Jose Luis","family":"G\u00f3rriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Bay\u00e9s-Gen\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.12.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13118"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000895"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu065"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1369"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12034"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs444"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/cc12503"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu292"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1697"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0717-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1660-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.19209"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22683"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2003.3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.04.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030112"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.03.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.07.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad031"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2017.07.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100418"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.009776"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.757"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00271.2016"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003738"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00410-w"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969246"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.067"}],"container-title":["Cardiorenal 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