{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:15:27Z","timestamp":1793387727561,"version":"4.5.0"},"reference-count":41,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>&lt;p&gt;Introduction: Direct comparisons of both short-term and long-term auxological outcomes of growth hormone therapy (GHT) between growth hormone deficiency (GHD) and small for gestational age (SGA) are scarce. Methods: One hundred three patients with GHD and 53 patients with SGA treated at our tertiary center were investigated. Short-term and long-term outcomes were compared between these groups using multivariable linear regression models with adjustment for age, sex, and height at therapy start, also allowing for sex-specific group comparisons. Results: Mean delta height standard deviation scores (SDS) after 1 year of treatment were significantly higher in GHD (0.90, CI: 0.82\u20130.99) compared to SGA (0.67, CI: 0.54\u20130.79) (p = 0.003) with no sex difference. As expected, the mean increase in height SDS at final height (FH) was significantly higher in GHD (2.21, CI: 2.00\u20132.42) compared to SGA (1.05, CI: 0.75\u20131.35) (p &lt; 0.001), leading to a target height corrected FH of \u22120.39 SDS (CI: \u22120.62 to \u22120.15) in GHD and \u22121.22 SDS (CI: \u22121.57 to \u22120.87) in SGA (p &lt; 0.001). Girls with GHD had a better long-term outcome, as did boys with SGA when compared to the respective opposite sex. The cut-off of delta height of 0.5 SDS during the first year had a low sensitivity to detect long-term non-responders. We found a relation between short-term and long-term outcomes in GHD but not in SGA (adjusted R2 = 0.66 vs. 0.01). Conclusion: In contrast to GHD, we observed practically no relationship between 1st-year and long-term outcomes in SGA patients treated with GH. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000538798","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T17:00:30Z","timestamp":1713546030000},"page":"344-356","source":"Crossref","is-referenced-by-count":3,"title":["Growth Hormone Therapy: Comparison of Short- and Long-Term Outcomes between Children with Growth Hormone Deficiency and Small for Gestational Age"],"prefix":"10.1159","volume":"98","author":[{"given":"Andreas","family":"Gleiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-594X","authenticated-orcid":false,"given":"Adalbert","family":"Raimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Haufler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana-Alexandra","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Sagmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/s0022-3476(03)00246-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0293"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/EC-22-0504"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1102968"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000347121"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000351025"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1934"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac517"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000516557"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.120188"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-007-1545-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000512336"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0165"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.05.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-007-1545-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2013.776110"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000358330"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000322878"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02057-x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00792"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00792"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7993"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000322878"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2008.08.001"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s13633-018-0064-3"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01053.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000348540"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-1055"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7110.708"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01808-4"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490425"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12677"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1581"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1471"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2023.101523"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1259"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-9-1"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2284"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/doi\/10.1159\/000538798\/4241783\/000538798.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000538798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:04:15Z","timestamp":1758297855000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000538798","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25637826","asserted-by":"subject"}]},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}