{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:07:02Z","timestamp":1790633222653,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> The widespread use of computed tomography as a screening tool for early lung cancer has increased detection of pulmonary lesions. It is common to encounter patients with more than one peripheral pulmonary nodule (PPN) of uncertain etiology. Shape-sensing robotic-assisted bronchoscopy (ssRAB) emerges as a potential alternative to biopsy multiple PPN, in addition to mediastinal staging in single anesthetic procedure. <b><i>Methods:<\/i><\/b> This is a single-center, retrospective review of 22 patients who underwent ssRAB for evaluation of two or more PPN, between November 2021 and April 2023 at Mayo Clinic, FL, USA. <b><i>Results:<\/i><\/b> A total of 46 PPNs were biopsied in 22 patients. All lesions were \u22642 cm with a median minimum and maximum cross-sectional lesion size of 1.40 cm and 1.05 cm, respectively. Diagnostic yield was 86.9% (<i>n<\/i> = 40), and target reach was 91.3% (<i>n<\/i> = 42). Most lesions were in the upper lobes, a solid pattern was found in 78.3% (<i>n<\/i> = 36), bronchus sign was present in 82.6% of cases (<i>n<\/i> = 38), 54.4% (<i>n<\/i> = 25) were malignant nodules, and 32.6% (<i>n<\/i> = 15) were benign. Fourteen patients had at least one malignant lesion out of two or more nodules sampled, and 10 patients had a malignant diagnosis for all sampled lesions. The complication rate was 9% (<i>n<\/i> = 2) with one case of bleeding and one of pneumothorax. <b><i>Conclusion:<\/i><\/b> This study is, to our knowledge, the first to assess the use and safety of ssRAB for diagnosis of multiple PPN in a single anesthetic event. This procedure will mainly impact management decisions and subsequently shorten the time from diagnosis to treatment. <\/jats:p>","DOI":"10.1159\/000538910","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T21:00:30Z","timestamp":1713819630000},"page":"397-405","source":"Crossref","is-referenced-by-count":15,"title":["Shape-Sensing Robotic-Assisted Bronchoscopy in the Multiple Pulmonary Nodule Diagnosis during a Single Anesthetic 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