{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:04:32Z","timestamp":1789423472373,"version":"build-2803163510"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Brain injury patterns of preterm infants with perinatal asphyxia (PA) are underreported. We aimed to explore brain magnetic resonance imaging (MRI) findings and associated neurodevelopmental outcomes in these newborns. Methods: Retrospective multicenter study included infants with gestational age (GA) 24.0\u201336.0 weeks and PA, defined as \u22652 of the following: (1) umbilical cord pH \u22647.0, (2) 5-min Apgar score \u22645, and (3) fetal distress or systemic effects of PA. Findings were compared between GA &amp;lt;28.0 (group 1), 28.0\u201331.9 (group 2), and 32.0\u201336.0 weeks (group 3). Early MRI (&amp;lt;36 weeks postmenstrual age or &amp;lt;10 postnatal days) was categorized according to predominant injury pattern, and MRI around term-equivalent age (TEA, 36.0\u201344.0 weeks and \u226510 postnatal days) using the Kidokoro score. Adverse outcomes included death, cerebral palsy, epilepsy, severe hearing\/visual impairment, or neurodevelopment &amp;lt;-1 SD at 18\u201324 months corrected age. Results: One hundred nineteen infants with early MRI (n = 94) and\/or MRI around TEA (n = 66) were included. Early MRI showed predominantly hemorrhagic injury in groups 1 (56%) and 2 (45%), and white matter (WM)\/watershed injury in group 3 (43%). Around TEA, WM scores were highest in groups 2 and 3. Deep gray matter (DGM) (aOR 15.0, 95% CI: 3.8\u201358.9) and hemorrhagic injury on early MRI (aOR 2.5, 95% CI: 1.3\u20134.6) and Kidokoro WM (aOR 1.3, 95% CI: 1.0\u20131.6) and DGM sub-scores (aOR 4.8, 95% CI: 1.1\u201321.7) around TEA were associated with adverse neurodevelopmental outcomes. Conclusion: The brain injury patterns following PA in preterm infants differ across GA. Particularly DGM abnormalities are associated with adverse neurodevelopmental outcomes. <\/jats:p>","DOI":"10.1159\/000538986","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T11:45:37Z","timestamp":1717674337000},"page":"616-626","source":"Crossref","is-referenced-by-count":17,"title":["Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia"],"prefix":"10.1159","volume":"121","author":[{"given":"Corline E.J.","family":"Parmentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"el Bakkali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise A.","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylke 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Haan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1637","authenticated-orcid":false,"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i1.67"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101304"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a9ef34"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2016.04.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2016.00114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12030645"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)80282-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3521"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01436-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.026"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.026"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2009.09.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2021.151469"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.05.033"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169442"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0141-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9030049"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2015.00097"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2022.151592"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.09.043"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5191"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/5\/616\/4283970\/000538986.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/121\/5\/616\/4283970\/000538986.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:17:44Z","timestamp":1745421464000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000538986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10,1]]},"published-print":{"date-parts":[[2024,9,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000538986","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25656270","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]}}}