{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:56:33Z","timestamp":1782820593025,"version":"3.54.5"},"reference-count":14,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Hepatocellular carcinoma (HCC) is a highly vascular malignancy with the potential for intravascular invasion. However, vascular extension into the cardiac chambers is extremely rare. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; We present a 25-year-old male patient in whom the investigation of a cardiac murmur led to the discovery of an intracardiac mass that proved to be advanced-stage HCC with vascular invasion of the right heart. The patient had a previously unknown non-cirrhotic chronic hepatitis B virus (HBV) infection. Despite antiviral therapy and systemic treatment for HCC, he eventually died about 1 month later due to disease progression. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This report highlights the importance of early HBV diagnosis and treatment for timely detection and management of HCC. Advanced-stage HCC, particularly with cardiac involvement, has an extremely poor prognosis. <\/jats:p>","DOI":"10.1159\/000539093","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T21:11:25Z","timestamp":1722028285000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Hepatocellular Carcinoma with Vascular and Cardiac Involvement in a Young Patient with Non-Cirrhotic Hepatitis B: A Case Report"],"prefix":"10.1159","author":[{"given":"In\u00eas","family":"Botto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Serrazina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Rodrigues","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Carvalhana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u00e7alo","family":"Nogueira-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Cortez-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2020.11.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00124-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7201a1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2013.05.004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i12.3462"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000511643"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.2.379"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.01.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06036.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2021.04.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-259"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i26.7893"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pjg\/article-pdf\/doi\/10.1159\/000539093\/4258184\/000539093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pjg\/article-pdf\/doi\/10.1159\/000539093\/4258184\/000539093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:18:42Z","timestamp":1745421522000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1159\/000539093","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}