{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:07Z","timestamp":1789010287256,"version":"build-2803163510"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>Introduction: Stimulated copeptin may provide an alternative to water deprivation testing (WDT) in the evaluation of polyuria-polydipsia syndrome (PPS). Though best studied, arginine stimulation alone produces a modest copeptin response in children. We investigated the effectiveness of the arginine + LevoDopa\/Carbidopa stimulation test (ALD-ST) for copeptin. Methods: 47 healthy short children (controls), 10 children with primary polydipsia, and 10 children with AVP deficiency received arginine hydrochloride (500 mg\/kg intravenously over 30 min) and Levodopa\/carbidopa (10:1 ratio; 175 mg of &lt;sc&gt;l&lt;\/sc&gt;-Dopa\/m2 BSA) orally. Serum copeptin was measured at 0, 60, 90, and 120 min. Results: In controls, ALD-ST increased copeptin from a median of 7.0 pmol\/L (IQR 5.0\u201310.0) to a peak of 44.0 pmol\/L (IQR 21.4\u2013181.0) between 60 and 120 min (p &lt; 0.001). Copeptin peak was higher in subjects who experienced nausea or vomiting (57%) than in those who did not (131.0 pmol\/L [IQR 42.5\u2013193.8] vs. 22.7 pmol\/L [IQR 16.0\u201333.7], p &lt; 0.001). While subjects with primary polydipsia had similar baseline (8.5 pmol\/L [IQR 8.0\u201311.0]) and stimulated (125.2 pmol\/L [IQR 87.6\u2013174.0]) copeptin levels as controls, subjects with AVP deficiency had lower baseline (2.5 pmol\/L [IQR 2.0\u20133.1]) and peak levels (4.6 pmol\/L [IQR 2.4\u20136.0]). A peak copeptin of \u22659.3 pmol\/L best predicted absence of complete or partial AVP deficiency with a sensitivity of 100% and specificity of 80%. Conclusions: ALD-ST induced a robust peak copeptin in healthy short children and children with primary polydipsia. Nausea\/vomiting, a side effect of ALD-ST, amplified the copeptin response. The ALD-ST may be a suitable initial screening test in children with PPS. <\/jats:p>","DOI":"10.1159\/000539208","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T17:00:32Z","timestamp":1714755632000},"page":"316-326","source":"Crossref","is-referenced-by-count":8,"title":["Copeptin Stimulation by Combined Intravenous Arginine and Oral LevoDopa\/Carbidopa in Healthy Short Children and Children with the Polyuria-Polydipsia Syndrome"],"prefix":"10.1159","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-0427","authenticated-orcid":false,"given":"Christine A.","family":"March","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sastry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McPhaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Garibaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac547"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803760"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306263"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.5.431"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac070"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13583"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14880"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000532015"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03671-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2046"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-020-01076-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-22-0033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000528661"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1977.tb07811.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-5-721"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5728-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1985.248.1.R78"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(88)80020-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2009.10.004"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1156-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14417"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03777-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14620"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.1.51"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.74.4.1548343"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0437"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/doi\/10.1159\/000539208\/4241104\/000539208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000539208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:03:57Z","timestamp":1758297837000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000539208","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]}}}