{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:19:50Z","timestamp":1791533990932,"version":"4.3.4"},"reference-count":34,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Our laboratory has been exploring the MRI detection of fetal brain injury, which previously provided a prognostic biomarker for newborn hypertonia in an animal model of cerebral palsy (CP). The biomarker relies on distinct patterns of diffusion-weighted imaging-defined apparent diffusion coefficient (ADC) in fetal brains during uterine hypoxia-ischemia (H-I). Despite the challenges posed by small brains and tissue acquisition, our objective was to differentiate between left and right brain ADC changes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A novel aspect involved utilizing three-dimensional rendering techniques to refine ADC measurements within spheroids encompassing fetal brain tissue. 25-day gestation age of rabbit fetuses underwent global hypoxia due to maternal uterine ischemia. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Successful differentiation of left and right brain regions was achieved in 28% of the fetal brains. Ordinal analysis revealed predominantly higher ADC on the left side compared to the right at baseline and across the entire time series. During H-I and reperfusion-reoxygenation, the right side exhibited a favored percentage change. Among these fetal brains, 73% exhibited the ADC pattern predictive of hypertonia. No significant differences between left and right sides were observed in patterns predicting hypertonia, except for one timepoint during H-I. This study also highlights a balance between left-sided and right-sided alterations within the population. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This study emphasizes the importance of investigating laterality and asymmetric hemispheric lesions for early diagnosis of brain injury, leading to CP. The technological limitations in obtaining a clear picture of the entire fetal brain for every fetus mirror the challenges encountered in human studies. <\/jats:p>","DOI":"10.1159\/000539212","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T06:54:17Z","timestamp":1715064857000},"page":"1-13","source":"Crossref","is-referenced-by-count":7,"title":["Distinguishing Laterality in Brain Injury in Rabbit Fetal Magnetic Resonance Imaging Using Novel Volume Rendering Techniques"],"prefix":"10.1159","author":[{"given":"Gaurav","family":"Ambwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-229X","authenticated-orcid":false,"given":"Zhongjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Won","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidhartha","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2001.0041"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24801"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.10.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.08.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0136"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3781"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.1689"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000538607"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2816-03.2004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24901"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000499960"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21738"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.59.6.824"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199909000-00008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5986-11.2012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101407"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1211"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.06.005"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21095"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0169-7439(89)80095-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000219"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-019-00743-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12170"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221101535"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.78.5.601"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1219943"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1661"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.81294"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-021-02863-z"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1063\/1.4972383"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2020.01.01"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2012.696736"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202304071"}],"updated-by":[{"DOI":"10.1159\/000545723","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000}}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dne\/article-pdf\/doi\/10.1159\/000539212\/4236193\/000539212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dne\/article-pdf\/doi\/10.1159\/000539212\/4236193\/000539212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:49Z","timestamp":1745421589000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1159\/000539212","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25750371","asserted-by":"subject"}]},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,6]]}}}