{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:45:24Z","timestamp":1784951124990,"version":"3.55.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: The objective of this study was to investigate the relationship between the activity of neutral \u03b1-glucosidase in seminal plasma and semen quality and to explore the effect of secretory capability of the epididymis on male fertility. Methods: A retrospective analysis of 542 men treated in the Center for Reproductive Medicine and Infertility from February to December 2022, the semen parameters and neutral \u03b1-glucosidase were tested and compared among different groups. These 542 men included normozoospermia, oligospermia, asthenospermia, and teratozoospermia. Results: There was statistical difference in neutral alpha-glucosidase (NAG) level among different groups with different sperm concentration, motility, and morphology (p &lt; 0.001). The NAG activity in seminal plasma was positively correlated with ejaculate volume and sperm concentration; meanwhile, a very weak positive correlation was found between NAG level and sperm motility, sperm morphology, respectively. Conclusions: Our results indicated that the secretion of NAG affected the volume, concentration, motility, and morphology of sperm to a certain extent. Given that NAG is a specific and marker enzyme in epididymis, where is the site of sperm maturation, we can conclude that there is a close relationship between NAG and sperm quality. Therefore, seminal plasma NAG has a definite clinical value in helping diagnosis of male infertility. <\/jats:p>","DOI":"10.1159\/000539218","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T01:37:08Z","timestamp":1715391428000},"page":"479-486","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Neutral Alpha-Glucosidase on Semen Parameters"],"prefix":"10.1159","volume":"108","author":[{"given":"Han","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Pu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.393"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0272.2002.00458.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2003.tb00866.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00795"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_56_18"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1990.tb01967.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155377"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114889"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1990.tb03234.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/and.12058"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/19396360902801935"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/01485019508987867"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37984-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ani13091483"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_3_20"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12630"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0589"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/and.12948"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02115"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.11.2904"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12523"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg306"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg456"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/and.12498"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091578"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.22037\/uj.v16i2.4756"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_116_19"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000511653"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/108\/6\/479\/4307423\/000539218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/108\/6\/479\/4307423\/000539218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:52Z","timestamp":1745421592000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2024,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000539218","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]}}}