{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:02:09Z","timestamp":1793239329906,"version":"4.5.0"},"reference-count":130,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Background: Eosinophils have numerous roles in type 2 inflammation depending on their activation states in the blood and airway or after encounter with inflammatory mediators. Airway epithelial cells have a sentinel role in the lung and, by instructing eosinophils, likely have a foundational role in asthma pathogenesis. Summary: In this review, we discuss various topics related to eosinophil-epithelial cell interactions in asthma, including the influence of eosinophils and eosinophil products, e.g., granule proteins, on epithelial cell function, expression, secretion, and plasticity; the effects of epithelial released factors, including oxylipins, cytokines, and other mediators on eosinophils, e.g., on their activation, expression, and survival; possible mechanisms of eosinophil-epithelial cell adhesion; and the role of intra-epithelial eosinophils in asthma. Key Messages: We suggest that eosinophils and their products can have both injurious and beneficial effects on airway epithelial cells in asthma and that there are bidirectional interactions and signaling between eosinophils and airway epithelial cells in asthma.<\/jats:p>","DOI":"10.1159\/000539309","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:00:51Z","timestamp":1718643651000},"page":"1033-1047","source":"Crossref","is-referenced-by-count":23,"title":["Eosinophil-Epithelial Cell Interactions in Asthma"],"prefix":"10.1159","volume":"185","author":[{"given":"Breanne N.","family":"Steffan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren C.","family":"Denlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-978X","authenticated-orcid":false,"given":"Mats W.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2010.00192.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.06.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00093"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12292"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00075"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/all.15751"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/all.15884"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05628-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3CE1021-545R"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3HI0821-432RR"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00101"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01030.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-32259-4_13"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00761"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/all.14421"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1201658"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0149MA"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238907"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182208"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064281"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00006"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.06.012"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0563-4"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s004080000042"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.08.003"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.77"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/136463"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02085-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.13.5.7576691"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0300-7"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159\/000237547"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00739.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.82"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217807"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00937-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0027OC"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7622"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00033"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04065.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01362.x"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111398"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00057"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0750OC"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.10.3980"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v94.8.2827.420a04_2827_2835"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119414"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975914"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.005"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.033"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01798"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600611"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00051"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0150OC"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.007"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-10-8"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1991.260.6.L530"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.2500\/108854199778339008"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02678.x"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00136"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00884.x"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30048-0"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01865-2021"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202209-1707OC"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01198-9"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/all.14297"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.09.024"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1339"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00136611"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03035.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00443-w"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.04.003"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051677"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1450"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.012"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2019.1584903"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580598"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo03551g"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8789"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.4.1201"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13e12.x"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.992783"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2013.05.001"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08228-y"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03386.x"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01515.x"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.7273"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00104"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.21.1.3517"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.6.1942"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.09.001"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.006"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050585"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00106"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.03.036"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.158886"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1744OC"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4018"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201603-0526LE"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.027"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901227"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.028"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.012"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02598.x"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12876"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032436"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3AB1117-455R"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.546218"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.123.6.2925"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/2.4.341"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.3.685"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90931-1"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1159\/000237414"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4861"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.05.010"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1038\/nm1462"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041901"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030509"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01695-0"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188302"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1039\/c7lc01357d"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01985-4"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0104-8"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66417"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.899368"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.3390\/cells12162067"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000539309\/4296743\/000539309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000539309\/4296743\/000539309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:20:52Z","timestamp":1745407252000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":130,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,4]]},"published-print":{"date-parts":[[2024,11,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000539309","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]}}}