{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:03Z","timestamp":1745468643376,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: Total anomalous pulmonary venous connection (TAPVC) has a low prenatal diagnostic rate. Therefore, we investigated whether Doppler waveforms with a low pulsatility in the pulmonary veins can indicate fetal TAPVC. Methods: This retrospective study included 16 fetuses with TAPVC, including 10 with complex congenital heart disease and 104 healthy fetuses that underwent fetal echocardiography. Pulmonary venous S and D wave flow velocities and the valley (representing the lowest velocity between the S and D waves) were measured. Valley indices I and II were then calculated as (velocity of valley\/greater of the S and D wave velocities) and (velocity of valley\/lesser of the S and D wave velocities), respectively. Results: Supra\/infracardiac TAPVC cases exhibited significantly greater valley indices than that of the healthy group. After adjusting for gestational age at fetal echocardiography, valley indices I (odds ratio [OR] 7.26, p &amp;lt; 0.01) and II (OR: 9.23, p &amp;lt; 0.01) were significant predictors of supra\/infracardiac TAPVC. Furthermore, valley indices I and II exhibited a high area under the curve for detecting supra\/infracardiac TAPVC, regardless of the presence of pulmonary venous obstruction. Conclusion: The valley index may be a useful tool for the detection of fetal TAPVC. <\/jats:p>","DOI":"10.1159\/000539314","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T21:00:26Z","timestamp":1716238826000},"page":"445-452","source":"Crossref","is-referenced-by-count":0,"title":["Valley Index as a Predictor of Prenatal Diagnosis of Total Anomalous Pulmonary Venous Connection"],"prefix":"10.1159","volume":"51","author":[{"given":"Wakako","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kae","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugutoshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiyu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11093"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22973"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.7.1193"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18907"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-010-9788-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13357"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6115"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437597.44550.5d"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/5\/445\/4283320\/000539314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/5\/445\/4283320\/000539314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:20:54Z","timestamp":1745421654000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10,1]]},"published-print":{"date-parts":[[2024,10,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000539314","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25847371","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2024,5,20]]}}}