{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T23:31:51Z","timestamp":1775345511618,"version":"3.50.1"},"reference-count":46,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Introduction: Immunoglobulins (Ig) reactive with \u03b1-melanocyte-stimulating hormone (\u03b1-MSH), an anorexigenic neuropeptide, are present in humans and were previously associated with eating disorders. In this longitudinal study involving patients with anorexia nervosa (AN), we determined whether \u03b1-MSH in serum is bound to IgG and analyzed long-term dynamics of both \u03b1-MSH peptide and \u03b1-MSH-reactive Ig in relation to changes in BMI and gut microbiota composition. Methods: The study included 64 adolescents with a restrictive form of AN, whose serum samples were collected at hospital admission, discharge, and during a 1-year follow-up visit and 41 healthy controls, all females. Results: We found that in both study groups, approximately 40% of serum \u03b1-MSH was reversibly bound to IgG and that levels of \u03b1-MSH-reactive IgG but not of \u03b1-MSH peptide in patients with AN were low at hospital admission but recovered 1 year later. Total IgG levels were also low at admission. Moreover, BMI-standard deviation score correlated positively with \u03b1-MSH IgG in both groups studied but negatively with \u03b1-MSH peptide only in controls. Significant correlations between the abundance of specific bacterial taxa in the gut microbiota and \u03b1-MSH peptide and IgG levels were found in both study groups, but they were more frequent in controls. Conclusion: We conclude that IgG in the blood plays a role as an \u03b1-MSH-binding protein, whose characteristics are associated with BMI in both patients with AN and controls. Furthermore, the study suggests that low production of \u03b1-MSH-reactive IgG during the starvation phase in patients with AN may be related to altered gut microbiota composition. <\/jats:p>","DOI":"10.1159\/000539316","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:00:41Z","timestamp":1718139641000},"page":"907-920","source":"Crossref","is-referenced-by-count":9,"title":["Long-Term Dynamics of Serum \u03b1-MSH and \u03b1-MSH-Binding Immunoglobulins with a Link to Gut Microbiota Composition in Patients with Anorexia Nervosa"],"prefix":"10.1159","volume":"114","author":[{"given":"Jochen","family":"Seitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Lahaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia 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