{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:37:07Z","timestamp":1788187027296,"version":"build-2803163510"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Atopic dermatitis (AD) is a common chronic skin disease with an inflammatory pathophysiology that includes the activation of the innate and adaptive immune systems. We aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and eosinophil-to-neutrophil ratio (ENR) in AD patients, according to age and disease severity. <b><i>Methods:<\/i><\/b> This is a retrospective, population-based cohort study conducted between the years 2005 and 2020, comparing hematological markers of AD patients and sex-age-ethnicity-matched controls. AD patients were further divided by age and disease severity (mild, moderate-to-severe AD). We created a decision tree to predict moderate-severe AD. <b><i>Results:<\/i><\/b> A total of 13,928 patients with AD were included in this study: 6,828 adults and 7,100 children, with 13,548 controls. NLR, PLR, and ELR were lower in children compared to adults (<i>p<\/i> values &lt;0.001). NLR, PLR, ELR, and ENR were increased in moderate-severe AD patients compared to mild AD patients (<i>p<\/i> values &lt;0.001). PLR, ELR, and ENR were increased in AD patients versus controls (<i>p<\/i> values &lt;0.001), with an additional increase in the NLR of moderate-to-severe AD patients. Patients with an ELR &lt;0.21, a PLR &gt;161, and ENR \u22640.016 should be considered high risk for developing severe AD, as well as patients with an ELR &gt;0.21 and age at diagnosis &lt;30 or age &gt;30 years and mean platelet volume \u22649. <b><i>Conclusion:<\/i><\/b> Hematological ratios were significantly higher in moderate-to-severe AD patients, compared to mild AD patients. Hematological markers were lower in children with AD compared to adults, except for ENR, likely reflecting age-related changes in blood count parameters. These markers can assist in the management and follow-up of AD patients.<\/jats:p>","DOI":"10.1159\/000539365","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T17:00:44Z","timestamp":1716915644000},"page":"597-605","source":"Crossref","is-referenced-by-count":11,"title":["Hematological Markers in Children and Adults with Atopic Dermatitis: A Retrospective Cohort Study"],"prefix":"10.1159","volume":"240","author":[{"given":"Sarah","family":"Weissmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Shira","family":"Babyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Golan-Tripto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Horev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107773"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165577"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.06.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48448"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.10.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8252-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2015.10.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.12659\/msm.900212"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1852413"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v49i5.204"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.665827"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0356-2019"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.017"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2018_023"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.16615"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.09.005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01867"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062201"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_509_17"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082235"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00834-4"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/4\/597\/4262507\/000539365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/240\/4\/597\/4262507\/000539365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:21:39Z","timestamp":1745407299000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2024,8,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000539365","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}