{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:07Z","timestamp":1745468647594,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Introduction: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is frequently associated with various gastrointestinal symptoms, including abdominal pain, vomiting, and diarrhea. Moreover, several cases of refractory diarrhea have been reported after COVID-19 recovery. Herein, we present a case of severe refractory diarrhea associated with COVID-19. Case Presentation: A 50-year-old man with no comorbidities was admitted to our hospital with SARS-CoV-2 pneumonia. His respiratory status deteriorated, and ventilatory management, including extracorporeal membrane oxygenation, was needed. The patient\u2019s respiratory condition improved, resulting in a transfer to another hospital for rehabilitation. However, the patient developed diarrhea that worsened to 6,000\u20137,000 mL\/day, and he was transferred to our hospital. We diagnosed the patient with enterocolitis caused by cytomegalovirus infection and treated him with ganciclovir on day 5 after transfer to our hospital. The diarrhea did not improve. We suspected enterocolitis associated with COVID-19 and administered a methylprednisolone pulse (intravenous injection, 1,000 mg\/day for 3 days) on day 10 after transfer, resulting in a marked improvement in his symptoms. The prednisolone dose was tapered, and no recurrence of diarrhea was observed thereafter. Conclusion: The prevalence of COVID-19-associated enterocolitis is low, and the pathogenesis of the disease remains unclear. Prednisolone administration should be considered in cases of post-COVID-19 symptoms of severe diarrhea due to a possible abnormal immune response related to COVID-19. <\/jats:p>","DOI":"10.1159\/000539413","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T08:24:27Z","timestamp":1724747067000},"page":"318-326","source":"Crossref","is-referenced-by-count":0,"title":["Severe Refractory Diarrhea Associated with COVID-19: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Akiyoshi","family":"Tsuboi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuya","family":"Shigenobu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yuge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Arihiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1470"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.04.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2020-000417"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.065"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221118403"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/den.13994"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325937"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001755"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.42"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-022-01598-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24105"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.793"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40286"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.048"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29096"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.12890\/2020_001911"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23203"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31129-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.26456"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crg\/article-pdf\/doi\/10.1159\/000539413\/4242348\/000539413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crg\/article-pdf\/doi\/10.1159\/000539413\/4242348\/000539413.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:22:21Z","timestamp":1745421741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000539413","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25858507","asserted-by":"subject"}]},"ISSN":["1662-0631"],"issn-type":[{"type":"electronic","value":"1662-0631"}],"subject":[],"published":{"date-parts":[[2024,6,14]]}}}