{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:25:18Z","timestamp":1758313518954,"version":"3.44.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<jats:p>Introduction: Patent foramen ovale (PFO)-stroke, a form of cryptogenic stroke, has certain identifying clinical and imaging features. However, data describing this stroke type remain inconsistent. This study examined the potential variations in PFO-stroke features, depending on age. Methods: From a hospital registry, cryptogenic stroke patients were retrospectively selected, and PFO-strokes were identified by the presence of &gt;10 microembolic signals on transcranial Doppler saline agitation test. Cryptogenic strokes were grouped according to age (&lt;70 as young, \u226570 as elderly). Clinical and imaging variables of PFO-strokes and non-PFO-strokes were compared, with and without age considered. Results: Of the 462 cryptogenic patients, 30.5% (141\/462) were PFO-strokes, while majority (321\/462) had no PFO. When cryptogenic strokes were analyzed by age, the significant difference was noted in the lesion number, pattern, and side. A single (72.8 vs. 57.9%, p = 0.020) and a small single lesion (51.1 vs. 35.5%, p = 0.039) were frequently seen in the younger PFO-strokes than the non-PFO counterpart, while mixed territory lesions identified the elderly PFO-strokes (30.6 vs. 8.9%, p = 0.001). A multivariate logistic regression analysis of PFO-strokes further showed that age was independently associated with lesion side (OR 1.12 [1.05\u20131.20], p &lt; 0.001) and lesion number (OR 1.06 [1.02\u20131.10], p = 0.005). Conclusions: Incorporating age-specific imaging criteria in the identification of PFO-strokes may be of additional value. Further, PFO may remain contributory to the stroke risk in the elderly, in association with vascular risk factors. <\/jats:p>","DOI":"10.1159\/000539535","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T17:00:25Z","timestamp":1717002025000},"page":"409-414","source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Variations in Patterns of Patent Foramen Ovale-Stroke versus Other Cryptogenic Stroke"],"prefix":"10.1159","volume":"54","author":[{"given":"Monique Therese S.","family":"Punsalan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-118X","authenticated-orcid":false,"given":"Han-Yeong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1433-8005","authenticated-orcid":false,"given":"Keun-Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Young","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-1111","authenticated-orcid":false,"given":"Eung-Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wookjin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Wan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/hs0302.104543"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a08d59"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1122"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.647"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.908533"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002459"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.35"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2006.00021.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.12.011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001119"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.085"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2004.04.051"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v85.11.3144.bloodjournal85113144"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.02278"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30167-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1948"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.31728\/jnn.2023.00140"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ced\/article-pdf\/doi\/10.1159\/000539535\/4252774\/000539535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000539535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:03:05Z","timestamp":1758297785000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,4]]},"published-print":{"date-parts":[[2025,6,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000539535","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25907917","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2024,5,29]]}}}