{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:35:18Z","timestamp":1747193718145,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: Suture tensile properties have only been tested in extrauterine environments. Amniotic fluid (AF) is a complex milieu of enzymes and inflammatory factors. This study tested the mechanical properties of sutures with a variety of inherent properties, after exposure to AF from patients with conditions prompting fetal intervention. Methods: AF was obtained from 3 patients with twin-twin transfusion syndrome (TTTS), and 3 patients with neural tube defects. Six types of 2-0 sutures were placed on 1.2 N of tension to mimic placement in vivo, and incubated in AF at 37\u00b0C (98.6\u00b0F). These included ethylene terephthalate (Ethibond), glycomer 631 (V-Loc), poliglecaprone 25 (Monocryl), poly-4-hydroxybutyrate (Monomax), polydioxanone (PDS), and polyglactin 910 (Vicryl). Failure load, stress, strain, and initial modulus were tested after 24 h of incubation and after 4 weeks, and compared with control (unincubated) sutures using t tests, Kruskal-Wallis tests, and stress-strain curves. Results: Poliglecaprone 25 and polyglactin 910 dissolve more quickly in AF compared to outside the uterus, disintegrating at 4 weeks. Ethylene terephthalate and PDS experienced little change across 4 weeks of incubation. Glycomer 631 and poly-4-hydroxybutyrate exhibited interesting behavior in AF: glycomer 631 became more deformable at 24 h but later regained toughness by 4 weeks, while poly-4-hydroxybutyrate became tougher and in some cases stronger with time in AF. As a class, braided sutures act more like rigid materials, and monofilaments act like deformable plastics. Conclusion: These findings along with other suture characteristics such as ease of handling and availability may inform fetal intervention teams as they optimize procedures in a relatively new surgical field. <\/jats:p>","DOI":"10.1159\/000539561","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T21:00:43Z","timestamp":1717189243000},"page":"463-473","source":"Crossref","is-referenced-by-count":0,"title":["Suture Characteristics after Exposure to Amniotic Fluid from an in vitro Model of Fetal Surgery"],"prefix":"10.1159","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-1192","authenticated-orcid":false,"given":"Cara","family":"Buskmiller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessian L.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena Sanz","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopali","family":"Donepudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Chilukuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Belfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Nassr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2021.11.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.08.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211290"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e73"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107424"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00313.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1713082"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5894"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00070.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb09975.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33171"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2010.538413"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X10395010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2023.1157661"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-11-36"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.847"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000835"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000525768"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.051"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/5\/463\/4283335\/000539561.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/51\/5\/463\/4283335\/000539561.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:23:35Z","timestamp":1745421815000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10,1]]},"published-print":{"date-parts":[[2024,10,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000539561","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.25942723","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}