{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:14Z","timestamp":1745468654065,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<b><i>Introduction:<\/i><\/b> Chronic rhinosinusitis (CRS) can be associated with tumors involving the maxillary sinus, but outcomes after undergoing maxillectomy with free flap reconstruction remain unclear. <b><i>Methods:<\/i><\/b> A retrospective analysis of medical records was performed to evaluate evidence of CRS in patients who underwent maxillectomy with free flap reconstruction at a single tertiary care academic institution from 2013 through 2020. <b><i>Results:<\/i><\/b> Eighty-four patients were assessed. Nineteen (22.6%) patients were diagnosed with CRS after surgery, 23 (27.4%) patients were treated for sinus symptoms, and 49 (58.3%) had radiographic evidence of sinus inflammation for more than 6 months. Risk factors for requiring sinus treatment included adjuvant or neoadjuvant chemotherapy (<i>p<\/i> = 0.002) and pre-operative use of sinus medication (<i>p<\/i> &lt; 0.001). Radiographic evidence of sinusitis 6 months after surgery is also closely associated with sinusitis treatment (<i>p<\/i> = 0.051). <b><i>Conclusions:<\/i><\/b> CRS may be underdiagnosed in patients undergoing maxillectomy with microvascular reconstruction. Further evaluation into patient sinus disease and symptoms following neoplastic surgery may lead to a higher quality of life in some long-term survivors. <\/jats:p>","DOI":"10.1159\/000539604","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Rhinosinusitis Risk after Maxillectomy with Microvascular Reconstruction"],"prefix":"10.1159","author":[{"given":"Michael T.","family":"Werner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kush","family":"Panara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendall K.","family":"Tasche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason G.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabie M.","family":"Shanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Cannady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90127-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.129618"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198901000-00011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24435"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4083"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2624"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02907740"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5114-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000701"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24423"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3004-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815571536"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25435"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/orl\/article-pdf\/doi\/10.1159\/000539604\/4252494\/000539604.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/orl\/article-pdf\/doi\/10.1159\/000539604\/4252494\/000539604.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:23:56Z","timestamp":1745421836000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1159\/000539604","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}