{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:52:02Z","timestamp":1770274322870,"version":"3.49.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Local recurrence of conjunctival melanoma (CM) is common after excision. Local radiotherapy is an effective adjuvant treatment option, and brachytherapy with ruthenium-106 (<sup>106<\/sup>Ru) is one such option. Thus, herein, we aimed to describe our experience with and the clinical results of post-excision adjuvant <sup>106<\/sup>Ru plaque brachytherapy in patients with CM. <b><i>Methods:<\/i><\/b> Nineteen patients (8 men and 11 women) received adjuvant brachytherapy with a <sup>106<\/sup>Ru plaque after tumor excision. The mean adjuvant dose administered was 109 Gy (range, 80\u2013134 Gy), and a depth of only 2.2 mm was targeted because the tumor had been excised. A full ophthalmological examination including visual acuity testing, slit-lamp examination, and indirect ophthalmoscopy was performed before therapy and at every postoperative follow-up. The mean follow-up period was 62 months (range, 2\u2013144 months). <b><i>Results:<\/i><\/b> Three patients developed a recurrence in a nontreated area, at either the conjunctiva bulbi or the conjunctiva tarsi. None of the patients developed a recurrence in the treated area. The local control rate was 84% (16\/19). <b><i>Conclusion:<\/i><\/b> <sup>106<\/sup>Ru plaque brachytherapy is an effective adjuvant treatment to minimize the risk of local recurrence after excision of a CM. Patients have to be followed up regularly and carefully for the early detection of recurrence. <\/jats:p>","DOI":"10.1159\/000539684","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:00:41Z","timestamp":1718139641000},"page":"162-167","source":"Crossref","is-referenced-by-count":1,"title":["Adjuvant Brachytherapy with Ruthenium-106 to Reduce the Risk of Recurrence of Conjunctival Melanoma after Excision"],"prefix":"10.1159","volume":"10","author":[{"given":"Luise","family":"Grajewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Kneifel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"W\u00f6sle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilja F.","family":"Ciernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1992.tb08566.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13207"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.157933"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.2.167"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.021"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.85"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.3200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(88)33059-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.11.1497"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(01)01085-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35693"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0344"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1109651"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1027432"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3182611670"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-015-0147-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/349162"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-39-467-867"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.4.252"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316293"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0879-z"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.154"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(82)34761-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-1080-y"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300686"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.086850"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/oop\/article-pdf\/10\/3\/162\/4273335\/000539684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/oop\/article-pdf\/10\/3\/162\/4273335\/000539684.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:23Z","timestamp":1745421863000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9,2]]},"published-print":{"date-parts":[[2024,9,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000539684","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}