{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:13:52Z","timestamp":1776298432099,"version":"3.50.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Rheumatoid arthritis (RA) combined with hashimoto thyroiditis (HT) is an important cause of various fatal comorbidities of RA. There is no precise conclusion about the cause of this disease. Methods: Peripheral blood and synovial tissue were collected from healthy participants, patients with RA, and patients with both RA and HT. Immunofluorescence staining and Pearson correlation analysis were used to detect the levels of \u03b3\u03b4TCR and the correlation between IL-17 and p-STAT3, respectively. ELISA, chemiluminescence assays, qRT-PCR and Western blot were performed to detect the levels of IgG, IgM, IFN-\u03b3, IL-1\u03b2, TNF-\u03b1, Tg-Ab, Tpo-Ab, IL-17, IL-2, p-SATA3, and STAT3, respectively. Results: There was increased proportion of \u03b3\u03b4T cells, IL-17, and p-STAT3 levels in RA and HT patients. IL-17 was positively correlated with p-STAT3. \u03b3\u03b4T cells significantly promoted the expression of IgG, Tg-Ab, Tpo-Ab, and IL-17. When \u03b3\u03b4T and human fibroblast-like synoviocytes (FLSs) were co-cultured, the levels of IL-2, IFN-\u03b3, IL-1\u03b2, TNF-\u03b1, and IL-17 were increased, and the IL-17\/STAT3 signaling pathway was activated. When IL-17-silenced \u03b3\u03b4T cells and STAT3-silenced FLSs were co-cultured, the levels of IL-1\u03b2 and TNF-\u03b1 in FLSs were significantly decreased. Furthermore, when STAT3-silenced FLSs were added to the co-culture medium of B cells and \u03b3\u03b4T cells, the levels of IL-1\u03b2 and TNF-\u03b1 were also decreased significantly. Conclusion: \u03b3\u03b4T cells induced RA directly or by stimulating B cells to activate STAT3 through IL-17. <\/jats:p>","DOI":"10.1159\/000539703","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1154-1165","source":"Crossref","is-referenced-by-count":4,"title":["\u03b3\u03b4T Cells Induce the Inflammatory Response of Human Fibroblast-Like Synoviocytes Directly or by Stimulating B Cells to Activate IL-17\/STAT3 Signaling Pathway"],"prefix":"10.1159","volume":"185","author":[{"given":"Fang","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunpan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.56"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111076"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.43"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3384"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1992.tb03221.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0631-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.11.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109456"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12993"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.082"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1552266"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_412_16"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-021-00620-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47860"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00699.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5332"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4430"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.06.010"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/art.30093"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361206"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/art.22033"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90235-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C600321200"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/art.21942"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/art.20302"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801882"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/ar4179"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/12\/1154\/4310784\/000539703.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/185\/12\/1154\/4310784\/000539703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:36Z","timestamp":1745421876000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,9]]},"published-print":{"date-parts":[[2024,12,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000539703","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]}}}