{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:18:51Z","timestamp":1782184731803,"version":"3.54.5"},"reference-count":22,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<b><i>Introduction:<\/i><\/b> The optimal protocol for serial amnioinfusions to maintain amniotic fluid in pregnancies with early-onset fetal renal anhydramnios before 22 weeks is not known. We compared the performance of two different approaches. <b><i>Methods:<\/i><\/b> A secondary analysis was conducted of serial amnioinfusions performed by a single center during the external pilot and feasibility phases of the Renal Anhydramnios Fetal Therapy (RAFT) trial. During the external pilot, higher amnioinfusion volumes were given less frequently; in the feasibility study, smaller volume amnioinfusions were administered more frequently. Procedural details, complications, and obstetric outcomes were compared between the two groups using Pearson\u2019s \u03c7<sup>2<\/sup> or Fisher\u2019s exact tests for categorical variables and Student\u2019s <i>t<\/i> tests or Wilcoxon rank-sum tests for continuous variables. The adjusted association between procedural details and chorioamniotic separation was obtained through a multivariate repeated measure logistic regression model. <b><i>Results:<\/i><\/b> Eleven participants underwent 159 amnioinfusions (external pilot: 3 patients, 21 amnioinfusions; feasibility: 8 patients, 138 amnioinfusions). External pilot participants had fewer amnioinfusions (7 vs. 19.5 in the feasibility group, <i>p<\/i> = 0.04), larger amnioinfusion volume (750 vs. 500 mL, <i>p<\/i> &lt; 0.01), and longer interval between amnioinfusions (6 [4\u20137] vs. 4 [3\u20135] days, <i>p<\/i> &lt; 0.01). In the external pilot, chorioamniotic separation was more common (28.6% vs. 5.8%, <i>p<\/i> &lt; 0.01), preterm prelabor rupture of membranes (PPROM) occurred sooner after amnioinfusion initiation (28 \u00b1 21.5 vs. 75.6 \u00b1 24.1 days, <i>p<\/i> = 0.03), and duration of maintained amniotic fluid between first and last amnioinfusion was shorter (38 \u00b1 17.3 vs. 71 \u00b1 19 days, <i>p<\/i> = 0.03), compared to the feasibility group. While delivery gestational age was similar (35.1 \u00b1 1.7 vs. 33.8 \u00b1 1.5 weeks, <i>p<\/i> = 0.21), feasibility participants maintained amniotic fluid longer. <b><i>Conclusion:<\/i><\/b> Small volume serial amnioinfusions performed more frequently maintain normal amniotic fluid volume longer because of delayed occurrence of PPROM. <\/jats:p>","DOI":"10.1159\/000539732","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:00:41Z","timestamp":1718139641000},"page":"1-1","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Serial Amnioinfusion Strategies for Isolated Early-Onset Fetal Renal Anhydramnios"],"prefix":"10.1159","author":[{"given":"Joyce M.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet A.","family":"Baschat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith A.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Kush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Wolfson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Voegtline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie C.","family":"Jelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-8265","authenticated-orcid":false,"given":"Jena L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5658"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.21037\/tp-2020-fs-05"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000497472"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2022.08.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.1.32"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0367"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000339"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13532"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2022.07.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.14.5.291.296"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000445946"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00235-j"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2020.04.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01128-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5767"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16265-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-4056-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21153"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000507700"}],"container-title":["Fetal 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Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/doi\/10.1159\/000539732\/4246512\/000539732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/doi\/10.1159\/000539732\/4246512\/000539732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:25:02Z","timestamp":1745421902000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1159\/000539732","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]}}}