{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:21:49Z","timestamp":1770726109605,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"abstract":"<b><i>Introduction:<\/i><\/b> Aberrant fibrosis in central centrifugal cicatricial alopecia (CCCA) is thought to be driven by persistent low-grade inflammation, but the source of inflammation is unclear. Alterations in the scalp microbiota may contribute to inflammation and thus provide a target for therapeutic intervention. We sought to compare the bacterial and fungal cutaneous scalp microbiota in patients with CCCA versus controls. <b><i>Methods:<\/i><\/b> Six patients with CCCA and seven controls were sampled at the vertex scalp. 16S rRNA sequencing of V3-V4 region and internal transcribed spacer amplicon sequencing was used to compare bacterial and fungal microbiomes. <b><i>Results:<\/i><\/b> A significantly higher relative abundance of <i>Corynebacterium<\/i> was noted in patients with CCCA versus controls. No significant difference in scalp fungal or bacterial microbiota composition was observed. <b><i>Limitations:<\/i><\/b> V3-V4 sequencing can be limited in detection of major skin bacterial species. <b><i>Conclusion:<\/i><\/b> CCCA is characterized by a distinct bacterial microbiome community and high relative abundances of <i>Corynebacterium<\/i>. Future studies should characterize the relationship between <i>Corynebacterium<\/i> and scalp inflammation and the role it may play in the progression of CCCA. <\/jats:p>","DOI":"10.1159\/000539763","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["A Pilot Study Characterization of the Scalp Microbiome in Central Centrifugal Cicatricial Alopecia Shows Shift in <i>Corynebacterium<\/i>"],"prefix":"10.1159","author":[{"given":"Hunter J.","family":"Pyle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Gadre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamia A.","family":"Harris-Tryon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Aguh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215206"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10050864"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.12.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00209.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.1257"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001336"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat8329"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10119.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00208.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009581"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0470-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1209"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2017.06.1198"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.15156\/BIO\/2483915"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17041-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.024"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171079"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.016"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000539763\/4254893\/000539763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000539763\/4254893\/000539763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:25:35Z","timestamp":1745421935000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,20]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1159\/000539763","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,20]]}}}