{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:47:10Z","timestamp":1773146830485,"version":"3.50.1"},"reference-count":41,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Cancer"],"abstract":"<b><i>Introduction:<\/i><\/b> The Liver Imaging Reporting and Data System (LI-RADS) categorization has been proposed as a potential prognostic indicator for primary liver neoplasms in patients with liver cirrhosis or chronic hepatitis B. This multicenter study aimed to determine whether LI-RADS categorization can offer additional post-surgical prognostic value for intrahepatic cholangiocarcinoma (ICCA) when used in conjunction with the American Joint Committee on Cancer (AJCC) guidelines. <b><i>Methods:<\/i><\/b> Patients with high risk for hepatocellular carcinoma, surgically confirmed ICCAs, and available preoperative MRI were enrolled. LI-RADS categorization of ICCAs was performed using MRI features, and multivariate analyses were conducted incorporating LI-RADS category, AJCC staging, and clinicopathologic factors to evaluate their predictive value for postoperative recurrence-free survival (RFS) and overall survival (OS). In patients with early recurrence (&lt;2 years), the percentages of AJCC stage I and LR-M or LR tumor-in-vein (TIV) were calculated, respectively. <b><i>Results:<\/i><\/b> Among the 166 ICCAs analyzed, 13.3% (22\/166) were classified as LR-4\/5, 77.7% (129\/166) as LR-M, and 9.0% (15\/166) as LR TIV. Classifications according to the 8th AJCC guidelines for patients with available post-surgical pathologic data and follow-up imaging were 40.6% (63\/155) stage I tumors, 23.9% (37\/155) stage II, and 35.5% (55\/155) stage III. Multivariate analysis revealed that LI-RADS category (LR-M or LR-TIV) was a significant factor for predicting both RFS (hazard ratio [HR] = 2.86, <i>p<\/i> = 0.02) and OS (HR = 3.18, <i>p<\/i> = 0.03). Additionally, AJCC staging (II or III) was a significant factor for RFS (HR = 3.90, <i>p<\/i> &lt; 0.001) and OS (HR = 3.29, <i>p<\/i> &lt; 0.001), male sex was a significant factor for RFS (HR = 1.89, <i>p<\/i> = 0.006) and OS (HR = 2.23, <i>p<\/i> = 0.002), and positive resection margin was a significant factor for OS (HR = 1.91, <i>p<\/i> = 0.03). Among the 80 patients with early recurrence, 97.5% displayed LR-M or LR-TIV features, while 11.3% were AJCC stage I patients. <b><i>Conclusion:<\/i><\/b> The MRI-based preoperative LI-RADS categorization of ICCA provides additional post-surgical prognostic value beyond the AJCC guidelines, with significant implications for both RFS and OS. <\/jats:p>","DOI":"10.1159\/000539794","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T21:00:34Z","timestamp":1718398834000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["LI-RADS Category Can Be a Post-Surgical Prognostic Factor for Intrahepatic Cholangiocarcinoma in Patients with Liver Cirrhosis or Chronic Hepatitis B"],"prefix":"10.1159","author":[{"given":"Sungeun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyeon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boryeong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-8777","authenticated-orcid":false,"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0310-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.241"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13492"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.41"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2018.02.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00300-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001036"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61903-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.5137"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24720"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.543"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171187"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5035"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31175"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i27.4252"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000521747"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28354"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181290"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15196"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1148\/rg.239001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1774"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220884"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2021.0055"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30915-X"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.03.023"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09536-w"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e462e6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26714"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21759"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3850"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001118"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181485"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13309"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2021.06.424"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i12.419"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28218"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.963753"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy335"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318236c21d"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-015-2803-6"}],"container-title":["Liver Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/lic\/article-pdf\/doi\/10.1159\/000539794\/4252253\/000539794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/lic\/article-pdf\/doi\/10.1159\/000539794\/4252253\/000539794.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:25:49Z","timestamp":1745421949000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":41,"URL":"https:\/\/doi.org\/10.1159\/000539794","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26038354","asserted-by":"subject"}]},"ISSN":["2235-1795","1664-5553"],"issn-type":[{"value":"2235-1795","type":"print"},{"value":"1664-5553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]}}}