{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:46:52Z","timestamp":1794005212518,"version":"4.8.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Tachycardia caused by sympathetic overactivity impairs myocardial function and raises septic patients\u2019 mortality. This study examined whether tachycardia is associated with acute kidney injury (AKI) period-prevalence among critically ill patients with and without sepsis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In 328 patients (119 sepsis and 209 non-sepsis) admitted to our intensive care unit (ICU), we assessed heart rate at ICU admission, plasma neutrophil gelatinase-associated lipocalin (NGAL) and N-terminal pro-B-type natriuretic peptide, and urinary L-type fatty acid-binding protein and N-acetyl-\u03b2-&lt;sc&gt;d&lt;\/sc&gt;-glucosaminidase (NAG) at 0 and 48 h after admission. Tachycardia was defined as a heart rate above 100 beats\/min. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Tachycardia was independently correlated with AKI prevalence during the first week after ICU admission in the septic patients, but not in the non-septic patients. A dose-dependent increase in AKI period-prevalence was observed across ascending heart rate ranges. Furthermore, we discovered a dose-dependent increase in renal biomarker-positive patients regarding plasma NGAL and urinary NAG over increasing heart rate ranges 48 h after admission. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The findings revealed an independent relationship between tachycardia and AKI prevalence during the first week of ICU in septic patients. Heart rate was found to have a dose-dependent effect on AKI prevalence and renal insult monitored by biomarkers. <\/jats:p>","DOI":"10.1159\/000539808","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:46:41Z","timestamp":1721627201000},"page":"641-649","source":"Crossref","is-referenced-by-count":5,"title":["Tachycardia and Acute Kidney Injury among Critically Ill Patients with Sepsis: A Prospective Observational Study"],"prefix":"10.1159","volume":"53","author":[{"given":"Naoki","family":"Hayase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Isshiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318232e50c"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.069"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000673"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278477"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30037-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.051"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht386"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2020.08.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001431"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1662-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.01.009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0355-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.444"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0177-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2120-z"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/srep33077"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200710415"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.20134"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74811-X"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002721"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.039"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1623"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000280099"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/53\/8\/641\/4263613\/000539808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/53\/8\/641\/4263613\/000539808.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:25:54Z","timestamp":1745421954000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000539808","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26029756","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}