{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:12:06Z","timestamp":1792631526538,"version":"4.5.0"},"reference-count":31,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; This study aimed to investigate the differences between pregnant women with chronic hepatitis B virus (HBV) infection and intrafamilial infection and those without intrafamilial infection. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; HBV-DNA was extracted from the sera of 16 pregnant women with chronic hepatitis B (CHB) and their family members for gene sequencing and phylogenetic analyses. A total of 74 pregnant women with CHB were followed up from the second trimester to 3 months postpartum. Viral markers and other laboratory indicators were compared between pregnant women with CHB with and without intrafamilial infection. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The phylogenetic tree showed that HBV lines in the mother-spread pedigree shared a node, whereas there was an unrelated genetic background for HBV lines in individuals without intrafamilial infection. From delivery to 3 months postpartum, compared with those without intrafamilial infection, pregnant women with intrafamilial infection were related negatively to HBV-DNA (\u03b2 = \u22120.43, 95% confidence interval [CI]: \u22120.76 to \u22120.12, &lt;i&gt;p&lt;\/i&gt; = 0.009), HBeAg (\u03b2 = \u2212195.15, 95% CI: \u2212366.35 to \u221223.96, &lt;i&gt;p&lt;\/i&gt; = 0.027), and hemoglobin changes (\u03b2 = \u22128.09, 95% CI: \u221215.54 to \u22120.64, &lt;i&gt;p&lt;\/i&gt; = 0.035) and positively to changes in the levels of alanine aminotransferase (\u03b2 = 73.9, 95% CI: 38.92\u2013108.95, &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) and albumin (\u03b2 = 2.73, 95% CI: 0.23\u20135.23, &lt;i&gt;p&lt;\/i&gt; = 0.033). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The mother-spread pedigree spread model differs from that of non-intrafamilial infections. Pregnant women with intrafamilial HBV infection have less hepatitis flares and liver damage, but their HBV-DNA and HBeAg levels rebound faster after delivery, than those without intrafamilial infection by the virus. <\/jats:p>","DOI":"10.1159\/000539994","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1-1","source":"Crossref","is-referenced-by-count":1,"title":["Differences between Chronically Hepatitis B Virus-Infected Pregnant Women with and without Intrafamilial Infection: From Viral Gene Sequences to Clinical Manifestations"],"prefix":"10.1159","author":[{"given":"Fan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hankui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanju","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00549-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132926"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00517-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix461"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03304-w"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100889"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.051"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0296-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.058"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007674301936"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290330"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S276526"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00304-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1939"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00026-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9764-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-182"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu661"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp077"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210x.12628"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.027"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.04.012"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10591-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16123"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06634-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.008"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.006"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-021-00907-0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1460"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.03.006"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/int\/article-pdf\/doi\/10.1159\/000539994\/4246167\/000539994.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/int\/article-pdf\/doi\/10.1159\/000539994\/4246167\/000539994.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:27:41Z","timestamp":1745422061000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000539994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":31,"URL":"https:\/\/doi.org\/10.1159\/000539994","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26104861","asserted-by":"subject"}]},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}