{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:27Z","timestamp":1745468667050,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"abstract":"<jats:p>Introduction\nAmyotrophic lateral sclerosis (ALS) is characterized by motor, cognitive and behavioral impairment. There is a paucity of evidence about the cognitive\/behavioral features of ALS patients from India. We aimed to investigate the cognitive\/behavioral profile of ALS spectrum disorders in the Indian context.\nMethods\nSixty patients with ALS spectrum and 40 age, gender and education matched healthy controls were recruited. The scales used were: Addenbrooke\u2019s Cognitive Examination (ACE\u2013III) Clinical Dementia Rating (CDR) scale, and Frontal Systems Behavior Scale (FrSBe). \nResults\nThe median age of the overall cohort was 54 years (IQR, 14), and male-to-female ratio was 2.5:1. Median duration of illness of the cohort was 12 months (IQR, 12). Patients were classified as ALS with: normal cognition (ALS-cn, n=21), mild cognitive or behavioral deficits (ALS-ci\/bi, n=28), and Frontotemporal Dementia (ALS-FTD, n=11). ALS-cn had poorer scores compared to healthy controls in global cognition, memory, and language (p&amp;lt;0.05). ALS-ci\/bi performed poorer than healthy controls on all cognitive domains (p &amp;lt; 0.05). ALS-FTD had poorer scores than healthy controls and ALS-cn on all cognitive domains (p&amp;lt; 0.001). Behavioral assessment showed an increase in apathy among all subtypes. ALS-FTD showed significant worsening in disinhibition and executive function compared to ALS-cn and ALSci\/bi.\nConclusion\nOur findings suggest that there are key cognitive and behavior characteristics in Indian patients with ALS spectrum. This further strengthens the evidence of a cognitive continuum in ALS and FTD in a diverse context and highlights the importance of meticulous evaluation and correct diagnosis that would assist in better management.<\/jats:p>","DOI":"10.1159\/000540018","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T21:04:10Z","timestamp":1722287050000},"source":"Crossref","is-referenced-by-count":1,"title":["Cognitive and behavioural profile of patients with Amyotrophic Lateral Sclerosis spectrum in the Indian Context"],"prefix":"10.1159","author":[{"given":"Kosha","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faheem","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim Javed","family":"Mujawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Cranberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamuna","family":"Rajeshwaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Afsar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin","family":"Thanissery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishnavi","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bangalore Somashekar","family":"Keerthana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balu","family":"Shubhangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seena","family":"Vengalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saraswati","family":"Nashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Baskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Polavarapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veeramani","family":"Preethish-Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvarna","family":"Alladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atchayaram","family":"Nalini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,7,26]]},"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dem\/article-pdf\/doi\/10.1159\/000540018\/4258540\/000540018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dem\/article-pdf\/doi\/10.1159\/000540018\/4258540\/000540018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:27:52Z","timestamp":1745422072000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000540018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000540018","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}