{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:47:43Z","timestamp":1793123263269,"version":"4.5.0"},"reference-count":48,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Cannabis Cannabinoids"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The legalization of cannabis in Thailand has renewed interest in its traditional medical use. This study aimed to explore the prescribing patterns of traditional practitioners and assess the impact of cannabis oil on patients\u2019 quality of life, with a specific focus on comparing outcomes between cancer and non-cancer patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a prospective observational cohort study across 30 sites in 21 Thai provinces to analyze the use of \u201cGanja Oil,\u201d a cannabis extract in 10% coconut oil, prescribed for symptoms like pain, anorexia, and insomnia across a diverse patient group, including cancer and migraines. Quality of life was assessed using the Edmonton Symptom Assessment Scale (ESAS) and EQ-5D-5L at baseline, 1, 2, and 3 months. The study included a predefined subgroup analysis to compare the effects on cancer versus non-cancer patients. Data management was facilitated through Research Electronic Data Capture (REDCap), with statistical analysis performed using Stata\/MP. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 21,284 participants, the mean age was 54.10 \u00b1 15.32 years, with 52.49% being male. The baseline EQ-5D-5L index was 0.85 \u00b1 0.24. Significant differences in EQ-5D-5L indices were seen between cancer patients (0.79 \u00b1 0.32) and non-cancer patients (0.85 \u00b1 0.23; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001). ESAS scores also differed significantly between these groups for all symptoms, except anxiety. The most frequent prescription of Ganja Oil was oral administration at bedtime (88.26%), with the predominant dosage being three drops daily, approximately 0.204 mg of tetrahydrocannabinol in total. Posttreatment, significant improvements were noted: the EQ-5D-5L index increased by 0.11 points (95% CI: 0.11, 0.11; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) overall, 0.13 points (95% CI: 0.12, 0.14; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) for cancer patients, and 0.11 points (95% CI: 0.10, 0.11; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) for non-cancer patients. ESAS pain scores improved by \u22122.66 points (95% CI: \u22122.71, \u22122.61; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) overall, \u22122.01 points (95% CI: \u22122.16, \u22121.87; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) for cancer patients, and \u22122.75 points (95% CI: \u22122.80, \u22122.70; &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001) for non-cancer patients, with similar significant improvements in other symptoms. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our study indicates potential benefits of Ganja Oil for improving quality of life among Thai patients, as a complementary treatment. These findings must be viewed in light of the study\u2019s design limitations. Further controlled studies are essential to ascertain its efficacy and inform dosing guidelines. <\/jats:p>","DOI":"10.1159\/000540153","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1-1","source":"Crossref","is-referenced-by-count":6,"title":["Medical Cannabis Prescription Practices and Quality of Life in Thai Patients: A Nationwide Prospective Observational Cohort 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