{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:55:58Z","timestamp":1776707758458,"version":"3.51.2"},"reference-count":40,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Cancer"],"abstract":"<jats:p>Introduction: A prospective study was started in May 2016 to evaluate the efficacy and safety of particle therapy for intrahepatic cholangial carcinoma (ICC). To compare treatment modalities, we also conducted a meta-analysis of literature data and a systematic comparison using registry data. Methods: Patients who received particle therapy for ICC from May 2016 to June 2018 were registered. Nineteen manuscripts (4 particle therapy, 8 3D-CRT, 7 SBRT) were selected for the meta-analysis. Results: A total of 85 cases (proton beam therapy 59, carbon therapy 26) were registered. The median overall survival (OS) of the 85 patients was 22.1 months (95% CI: 12.9\u201331.3); the 1-, 2-, 3-, and 4-year OS rates were 70.9% (95% CI: 61.1\u201380.7%), 47.6% (36.8\u201358.4%), 37.7% (26.7\u201348.7%), and 22.7% (10.2\u201335.2%), respectively; and the 1-, 2-, 3-, and 4-year local recurrence rates were 8.2% (1.1\u201315.3%), 21.6% (9.3\u201333.9%), 33.4% (16.7\u201350.1%), and 33.4% (16.7\u201350.1%), respectively. In the meta-analysis and registry data, the 1-year OS for particle therapy, SBRT and 3D-CRT were 71.8% (95% CI: 64.6\u201377.8%), 59.2% (53.0\u201364.9%, p = 0.0573), and 47.2% (36.8\u201356.9%, p = 0.0004), respectively. The incidence of grade 3 or higher late non-hematological toxicity in the meta-analysis and registry data were 7.4\u201312% for particle therapy, 6.7\u201316.7% for SBRT, and 8.1\u201314.3% for 3D-CRT. Conclusions: Particle therapy achieved a good therapeutic effect for ICC, and a meta-analysis indicated that particle therapy is a better treatment modality than SBRT and 3D-CRT. <\/jats:p>","DOI":"10.1159\/000540291","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T21:01:05Z","timestamp":1724878865000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Particle Therapy for Intrahepatic Cholangiocarcinoma: A Multicenter Prospective Registry Study, Systematic Review and 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