{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:24:25Z","timestamp":1770906265216,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<b><i>Introduction:<\/i><\/b> Our aim was to investigate the incidence, comorbidities, and outcomes of fetuses with an elevated middle cerebral artery peak systolic velocity (MCA-PSV) &gt;1.5 multiples of median (MoM), despite normal hemoglobin (Hgb) levels on fetal blood sampling (FBS). <b><i>Methods:<\/i><\/b> A single-center observational retrospective cohort study of all fetuses undergoing FBS and MCA-PSV &gt;1.5 MoM. Only those fetuses with no or mild anemia were included. Indications for Doppler assessment, associated anomalies, and neonatal outcomes were collected. <b><i>Results:<\/i><\/b> Overall, 383 fetuses had an MCA-PSV &gt;1.5 MoM and underwent FBS. Twenty-three (6%) fetuses met our inclusion criteria and had no or only mild anemia. Associations with elevated MCA-PSV were elucidated in 12 of the 23 cases (52.2%) and included mild anemia (<i>n<\/i> = 2), intracranial hemorrhage (<i>n<\/i> = 3), genetic disease (<i>n<\/i> = 1), idiopathic nonimmune hydrops (NIH, <i>n<\/i> = 1), hypoxic-ischemic encephalopathy (<i>n<\/i> = 1), maternal and or fetal acidosis (<i>n<\/i> = 3), and fetal growth restriction (<i>n<\/i> = 1). Favorable perinatal outcomes were observed in truly unexplained 11 cases with no additional anomalies (47.8%). <b><i>Conclusion:<\/i><\/b> Elevated MCA-PSV &gt;1.5 MoM with normal Hgb levels is seen in 6% of pregnancies undergoing FBS and is often associated with other significant maternal or fetal problems. Those with unexplained and isolated MCA-PSV elevation have normal outcomes. <\/jats:p>","DOI":"10.1159\/000540342","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:15:29Z","timestamp":1721682929000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Elevated Middle Cerebral Artery Peak Systolic Velocity in Non-Anemic Fetuses: Providing a Better Understanding of Enigmatic Middle Cerebral Artery Peak Systolic Velocity"],"prefix":"10.1159","author":[{"given":"Saja","family":"Anabusi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-7622","authenticated-orcid":false,"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Shinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91317-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05060400.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.03.060"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4088"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00070.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.206"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12723"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20273"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(88)91896-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb16250.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.07.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12318"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24844"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02624-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197401000-00009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008746"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12549"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15142"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22593"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3953"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1517322"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/doi\/10.1159\/000540342\/4264523\/000540342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/doi\/10.1159\/000540342\/4264523\/000540342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:30:49Z","timestamp":1745422249000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000540342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":25,"URL":"https:\/\/doi.org\/10.1159\/000540342","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]}}}