{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:55:58Z","timestamp":1766159758382,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glomerular Dis"],"abstract":"<jats:p>Thrombotic microangiopathy (TMA) is a recognized sequela of inborn errors of metabolism impacting vitamin B12 (cobalamin) synthesis. Methylmalonic aciduria and homocystinuria, cobalamin deficiency type C is a well-known etiology for TMA. TMA has only rarely previously been reported in methionine synthase (cobalamin G) deficiency. Furthermore, results of only 7 kidney biopsies have previously been reported in this clinical setting. Here, we report a case of kidney- and glomerular-limited chronic active microangiopathy demonstrated on kidney biopsy in a patient with biochemically confirmed cobalamin G deficiency. A literature review of all prior reported cases is also presented and demonstrates hypertension, proteinuria, and hematuria to be common presenting symptoms. Age on onset ranged from 7 months to 14 years. Kidney-limited phenotype was less common and occurred only in older children. Acute kidney injury was more common in younger patients. Therapy with hydroxocobalamin and angiotensin-converting enzyme inhibitors resulted in variable clinical responses. <\/jats:p>","DOI":"10.1159\/000540382","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:00:37Z","timestamp":1727452837000},"page":"183-188","source":"Crossref","is-referenced-by-count":0,"title":["Kidney-Limited Microangiopathy Associated with Methionine Synthase (Cobalamin G) Deficiency in a Pediatric Patient: Case Report and Review of the Literature"],"prefix":"10.1159","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-2147","authenticated-orcid":false,"given":"Jonathan E.","family":"Zuckerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.05.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051190"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3615-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3348-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01364.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.06.054"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9803-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05370-8"}],"container-title":["Glomerular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/gdz\/article-pdf\/4\/1\/183\/4290910\/000540382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/gdz\/article-pdf\/4\/1\/183\/4290910\/000540382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:31:17Z","timestamp":1745422277000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000540382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000540382","archive":["Portico"],"relation":{},"ISSN":["2673-3633"],"issn-type":[{"type":"electronic","value":"2673-3633"}],"subject":[],"published":{"date-parts":[[2024,9,27]]}}}