{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:49:29Z","timestamp":1783021769115,"version":"3.54.6"},"reference-count":33,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be limited by the inadequacy of intact tissues, especially in patients with lymphoma, sarcoidosis, and lymph node tuberculosis. A novel technique called transbronchial node biopsy (TBNB) by forceps or cryoprobe has been proposed and studied to improve specimen quality and diagnostic yield. We performed a systematic review of studies describing the safety and sensitivity of EBUS-TBNB versus EBUS-TBNA in diagnosing intrathoracic lymphadenopathy\/masses. Methods: We systematically searched MEDLINE, Embase, Cochrane, and China National Knowledge Infrastructure to identify studies focusing on the application of EBUS-TBNB for diagnosis of intrathoracic lymphadenopathy. The quality of each study was evaluated using the QUADAS-2 tool. Using inverse-variance (I-V) weighting, we performed a meta-analysis of diagnostic yield estimations. We also reviewed the complications related to the procedure. Results: Thirteen studies were included in the final analysis. The meta-analysis yielded a pooled overall diagnostic yield of 77.80% (939\/1,207) for EBUS-TBNA and 86.01% (834\/958) for EBUS-TBNB, with an inverse-variance-weighted odds ratio of 3.13 (95% confidence interval [CI], 1.61\u20136.01; p = 0.0008) and I2 of 82%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of malignancy (including primary lung cancer and extrapulmonary malignancy) was 84.53% (590\/698) for EBUS-TBNA and 90.84% (476\/524) for EBUS-TBNB, with an I-V-weighted OR of 2.33 (95% CI, 1.15\u20134.74; p = 0.02) and I2 of 64%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of benignancy was 71.19% (252\/354) for EBUS-TBNA and 86.62% (233\/269) for EBUS-TBNB, with an I-V-weighted OR of 4.39 (95% CI, 2.00\u20139.65; p = 0.002) and I2 of 59%. The overall complications included bleeding (n = 11, 0.90%), pneumomediastinum (n = 6, 0.49%), pneumothorax (n = 6, 0.49%), pneumonia (n = 4, 0.33%), respiratory failure (n = 1, 0.08%), and haemoptysis (n = 1, 0.08%). The funnel plot analysis illustrated no major publication bias. Conclusions: EBUS-TBNB improves the overall diagnostic yield of sampling intrathoracic lymphadenopathy and mass lesions relative to EBUS-TBNA. The complication rate of EBUS-TBNB is higher than that of EBUS-TBNA but reportedly lower than that of surgical biopsies. <\/jats:p>","DOI":"10.1159\/000540859","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T21:01:15Z","timestamp":1723582875000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Comparison between Endobronchial Ultrasound-Guided Transbronchial Node Biopsy and Transbronchial Needle Aspiration: A Meta-Analysis"],"prefix":"10.1159","author":[{"given":"Wuchen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quncheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181753b5e"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318223c3fe"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.175884"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1216"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202103-366OC"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.08.106"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033311"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010163"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13198"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000485661"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.031"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e3181af7a9f"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.03.069"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9341-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000350867"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000357358"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.051"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.10.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.08.106"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2021.0024"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000505936"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.808"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01814-x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00055-2021"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14422"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00448-2022"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00392-7"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12580"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.02.014"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-50"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.08.037"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/res\/article-pdf\/doi\/10.1159\/000540859\/4276479\/000540859.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/res\/article-pdf\/doi\/10.1159\/000540859\/4276479\/000540859.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:35:31Z","timestamp":1745422531000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000540859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1159\/000540859","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}