{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:19Z","timestamp":1747193599289,"version":"3.40.5"},"reference-count":31,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: The relationships between histopathology and imaging remain elusive, and investigating the underlying reasons for tumor microstructure leading to an imaging phenotype is of clinical importance. In the present study, a cross-sectional guided biopsy specimen was used to correlate prebioptic magnetic resonance imaging (MRI) with immunohistochemical staining of the histopathologic specimen using precise spatial biopsy localization. Methods: Twenty-seven patients with mass-forming cholangiocarcinoma (CCA) were included in the present analysis. All patients were imaged with a 1.5 T clinical scanner at least 1 month prior to biopsy. The contrast-enhanced dynamic sequences were analyzed with quantified signal intensities. The bioptic specimens were obtained by cross-sectional guided biopsy and further analyzed for cell density, proliferation index (Ki67), tumor-infiltrating lymphocytes, tumor-stroma ratio (TSR), and collagen. Results: There were no statistically significant correlations between MRI signal intensities and cell count, TSR, Ki67 index, and CD45 count. Only a moderate correlation was observed between relative signal intensities of the venous phase and the collagen-stained area (r = 0.40, p = 0.04). Conclusion: DCE-MRI is not associated with histopathological features in CCA. The complex interactions of tumor and tumor microenvironment are not reflected in the MRI phenotype. <\/jats:p>","DOI":"10.1159\/000540958","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T16:00:57Z","timestamp":1729526457000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Associations between Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Histopathological Features in Cholangiocarcinoma"],"prefix":"10.1159","author":[{"given":"Hans-Jonas","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Potratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f6rthe","family":"Jechorek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Ina","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-3943","authenticated-orcid":false,"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1289"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14964-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31288"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-00907-w"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(86)80075-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321299"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91167-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.11.036"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040805"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00444"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.512"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20406"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17752"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2022.110528"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-017-0239-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000454763"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132803"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-023-00576-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071314"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3846-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-020-00318-x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03803-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01320-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03018.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4811-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0300-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160639"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29020061"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5754\/hge13291"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180753"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/doi\/10.1159\/000540958\/4300751\/000540958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/doi\/10.1159\/000540958\/4300751\/000540958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:27Z","timestamp":1745422587000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000540958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":31,"URL":"https:\/\/doi.org\/10.1159\/000540958","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}