{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:16:33Z","timestamp":1774620993667,"version":"3.50.1"},"reference-count":47,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"abstract":"<jats:p>Introduction: Dental caries with pulp involvement potentially impacts the oral health-related quality of life (OHRQoL). This meta-analysis aimed to evaluate whether clinical consequences of pulp involvement due to dental caries impacts OHRQoL of children and adolescents. Methods: Observational studies evaluating whether children\/adolescents (population) with pulp involvement due to caries (exposition) compared with those without it (comparison) have more negative impact on their OHRQoL (outcome) were included. A systematic search was undertaken in August 2022 in seven databases. Alerts were set until August 2023. JBI Critical Appraisal tool for cross-sectional studies was used for methodological quality assessment. Random-effects meta-analyses were performed to calculate mean differences (MD) or standardized mean differences (SMD) of impact on OHRQoL. For studies with dichotomous outcome, meta-analysis calculated the odds ratio (OR). Robustness, heterogeneity, certainty of evidence, and publication bias were evaluated. Results: From 29 included studies, 14 assessed preschoolers, nine assessed schoolchildren, four assessed adolescents, and two assessed children\/adolescents. PUFA was the main index used to assess the exposure. ECOHIS (preschoolers) and CPQ (children\/adolescents) were the main tools used to assess the outcome. Only five articles fully adhered to the quality criteria. The meta-analyses found the following main results: (a) preschoolers: MD \u221210.79 (\u221216.50; \u22125.09); (b) schoolchildren: MD \u22125.12 (\u22127.51; \u22122.72); (c) adolescents: MD \u22121.86 (\u22124.59; 0.87); (d) overall impact: SMD \u22122.18; (CI: \u22123.21;\u22121.15) and OR 0.52 (CI: 0.30; 0.90). Conclusion: Pulp involvement impacted OHRQoL of children negatively. In adolescents, this impact was not observed. Results must be interpreted with caution due to very low certainty of evidence. <\/jats:p>","DOI":"10.1159\/000541027","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T21:03:55Z","timestamp":1725311035000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Clinical Consequences of Pulp Involvement due to Caries on Oral Health\u2010Related Quality of Life in Children and Adolescents: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","author":[{"given":"Patricia Papoula Gorni","family":"Reis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Costa","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido Artemio","family":"Mara\u00f1\u00f3n-V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Kelly da Silva","family":"Fidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-9401","authenticated-orcid":false,"given":"Lucianne Cople","family":"Maia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Mendes","family":"Soviero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517693566"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-020-00237-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000339491"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpped.2015.12.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12279"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00149.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000351693"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000345534"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/2333794x21999145"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2009.00514.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2011.00022.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12605"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1966-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.07.015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514557546"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0698-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7308\/aodontol\/2018.54.e13"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-023-02127-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03274-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12727"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10389-019-01106-z"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12844"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1626"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.20453\/reh.v29i1.3491"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/dj7040095"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_388_20"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12836"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2011.00625.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12086"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.54589\/aol.33\/1\/038"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2023.vol37.0041"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.b4009717"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1059-7"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12707"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1159\/000336387"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1159\/000506438"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0283-8"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12485"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2007.00347.x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100705"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-6"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-10-62"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2022.04.1723"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01677-0"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12494"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02371-8"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cre\/article-pdf\/doi\/10.1159\/000541027\/4282502\/000541027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cre\/article-pdf\/doi\/10.1159\/000541027\/4282502\/000541027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:56Z","timestamp":1745422616000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":47,"URL":"https:\/\/doi.org\/10.1159\/000541027","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26879866","asserted-by":"subject"}]},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]}}}