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Summary: With the continuous investigation of signaling pathways, RAS\/RAF\/MEK\/ERK signaling pathway and other signaling pathways including Hippo, JAK-STAT, Wnt, TGF-\u03b2, PI3K, Notch, and NF-\u03baB were confirmed to play an important role in the progression of CRSwNP. Among them, the abnormality of RAS\/RAF\/MEK\/ERK signaling pathway is accompanied by the abnormality of this apoptotic component, which may provide new research directions for targeting the components of signaling pathways to mediate apoptosis. Key Messages: Abnormalities in signaling pathways are particularly important in studying the pathogenesis and treatment of CRSwNP. 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