{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:10:24Z","timestamp":1775178624094,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"abstract":"<jats:p>Introduction: We assessed the association between increased body mass index (BMI) and rectal cancer outcomes. Methods: We included patients who underwent surgery for stage I-III rectal adenocarcinoma who were divided according to BMI at diagnosis: ideal BMI (18.5\u201324.9 kg\/m2) and increased BMI (\u226525 kg\/m2). Groups were compared using univariate association analyses relative to baseline characteristics, pathologic outcomes, overall survival (OS), and disease-free survival (DFS). Main outcome measures involved circumferential resection margin (CRM), pathologic TNM stage, total mesorectal incision (TME) grade, OS, and DFS. Results: 243 patients (64.6% male; median age 59 years) with a median BMI of 26.3 kg\/m2 were included. 62.1% had BMI \u226525 kg\/m2. Increased BMI patients had similar proportions of males (66.9% vs. 60.9%; p = 0.407) and comorbidities (ASA III: 47% vs. 37.4%; p = 0.24) to ideal BMI patients. There were no significant differences in cN1-2 stage (p = 0.279) or positive CRM (p = 0.062) rates. The groups had similar complete\/near-complete TME, pathologic TN stage, and survival rates. Pathologic and survival outcomes were also similar with a BMI cutoff of 30. Conclusions: There was a trend toward more nodal involvement in preoperative assessment and less CRM involvement in the final pathology of patients with increased BMI. Complete\/near-complete TME and survival rates were comparable between the groups. <\/jats:p>","DOI":"10.1159\/000541085","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T21:02:57Z","timestamp":1724446977000},"page":"194-203","source":"Crossref","is-referenced-by-count":3,"title":["Pathologic Outcomes and Survival in Patients with Rectal Cancer and Increased Body Mass Index"],"prefix":"10.1159","volume":"41","author":[{"given":"Sameh Hany","family":"Emile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Dasilva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Horesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Garoufalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Gefen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peige","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Berho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Wexner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073163"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j477"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.03.019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0450-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2018.59.6.703"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13131"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000097"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.03.037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-023-04447-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-88"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.09.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123798"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051222"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-020-00890-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1509140"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.09.014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2009.07.003"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dsu\/article-pdf\/41\/4\/194\/4292818\/000541085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dsu\/article-pdf\/41\/4\/194\/4292818\/000541085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:37:42Z","timestamp":1745422662000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10,24]]},"published-print":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000541085","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26819086","asserted-by":"subject"}]},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]}}}