{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:00Z","timestamp":1745468700311,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Because the prognosis of patients with peripheral T-cell lymphoma is poor compared to that of patients with B-cell lymphoma, we want to avoid further organ damage by eosinophilia. Moreover, in patients with some types of lymphoma, blood eosinophilia is implicated in a worse prognosis. To study the risk factors of eosinophilia, the association between lymphoma type, immunophenotypic features, and peripheral blood eosinophil counts were examined in the patients with mature T-cell lymphoma. Methods: We retrospectively examined 28 patients with mature T-cell lymphoma who were admitted to our hospital and whose immunophenotypic features were confirmed using flow cytometric, immunohistochemical analysis, or both between December 2012 and November 2023. Results: We report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma \u2013 not otherwise specified and CD3+CD4\u2212D8\u2212 (double-negative) phenotypes. Mild eosinophilia was observed in various types, but moderate and severe eosinophilia were observed in patients with peripheral T-cell lymphoma \u2013 not otherwise specified. Double-negative phenotype was rarely observed; however, all patients with double-negative phenotype exhibited peripheral blood eosinophilia. In addition, four of the five cases of the double-negative type were peripheral T-cell lymphoma \u2013 not otherwise specified. Conclusion: Here, we retrospectively examined patients with peripheral T-cell lymphoma whose immunophenotypic features were confirmed and report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma \u2013 not otherwise specified and CD3+CD4\u2212CD8\u2212 (double-negative) phenotypes. In addition, clinicians should be aware of the possible risk that patients with lymphocytic hypereosinophilic syndrome of the double-negative phenotype may develop peripheral T-cell lymphoma. <\/jats:p>","DOI":"10.1159\/000541097","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:39:56Z","timestamp":1726245596000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Possible Association of CD3+CD4\u2212CD8\u2212 Phenotype of T-Cell Lymphoma with Peripheral Blood Eosinophilia"],"prefix":"10.1159","author":[{"given":"Rie","family":"Tabata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-310342"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1101441"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v95.4.1207.004k34_1207_1213"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1057"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1008695"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6327"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.02.016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13441"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411503"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-37"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.049"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.108982"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000541097\/4277785\/000541097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000541097\/4277785\/000541097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:37:47Z","timestamp":1745422667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1159\/000541097","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2024,9,13]]}}}