{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:43:46Z","timestamp":1783464226691,"version":"3.55.0"},"reference-count":22,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<jats:p>Introduction: This systematic review and meta-analysis evaluated the quality of life (QoL) for nasopharyngeal carcinoma (NPC) patients with radiotherapy. Methods: A systematic literature search was performed to identify relevant studies published until March 2022. Quality evaluation and data extraction were performed for the included studies, and meta-analysis was performed using Stata. Results: Nine studies, including 1,659 patients, were eligible. Most QoL scales developed at the end of the treatment course and then followed by a gradual recovery to 1 year and more than 1 year after treatment. However, some items have not changed significantly and have a deteriorating trend. Items of cognitive functioning and constipation in EORTC QLQ-C30, and sexuality, felt ill, and weight gain in EORTC QLQ-H&amp;N35 showed that scales with follow-up of more than 1 year were worse than those within 1 year but still better than those after treatment. In the intensity-modulated radiotherapy (IMRT) subgroup in EORTC QLQ-C30, cognitive functioning was similar to those before, and there was no significant change in insomnia. There was no significant change in the teeth item in EORTC QLQ-H&amp;N35. In the IMRT subgroup, scales of swallowing, felt ill, and weight gain with follow-up of more than 1 year were worse than those within 1 year. Conclusion: The QoL of patients with NPC is significantly impaired after radiotherapy-treated compared to baseline, and most of these items will gradually improve. <\/jats:p>","DOI":"10.1159\/000541124","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:11:48Z","timestamp":1725621108000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Radiotherapy-Related Quality of Life in Nasopharyngeal Carcinoma Patients: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","author":[{"given":"Kai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.585046"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1626"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.08.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-39"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3747\/co.22.2323"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-2-120"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00930"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-015-0638-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2015.961427"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26634"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205063"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.09.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1283422"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0213-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.033"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.6.533"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20378"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110324"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200137"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05077-5"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/orl\/article-pdf\/doi\/10.1159\/000541124\/4289620\/000541124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/orl\/article-pdf\/doi\/10.1159\/000541124\/4289620\/000541124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:07Z","timestamp":1745422687000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1159\/000541124","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}