{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:45:28Z","timestamp":1778525128523,"version":"3.51.4"},"reference-count":13,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: Posterior urethral valve (PUV) is a major cause of congenital bladder dysfunction, often persisting despite treatment. Emerging therapies, including anticholinergics and \u03b1-1 blockers, offer potential but lack clear guidelines. This study evaluates their effectiveness in improving bladder function after valve fulguration. Methods: Twenty PUV patients, aged \u22653 years, were randomized into anticholinergic (group A, n = 11) and \u03b1-1 adrenergic blocker (group B, n = 9) groups post-fulguration. Follow-up included clinical, radiological, and urodynamic assessments 6 months posttreatment initiation. Results: In group A, the mean maximum detrusor pressure (P&lt;sub&gt;det&lt;\/sub&gt;) decreased from 30.17 to 23.45 cm H&lt;sub&gt;2&lt;\/sub&gt;O (p = 0.033). Two patients normalized from high detrusor pressure (&gt;40 cm H&lt;sub&gt;2&lt;\/sub&gt;O). In group B, 1 patient retained high detrusor pressure posttreatment. Group B improved in average urinary flow (Q avg) and maximum flow rate (Q max), with all patients having initially low Q avg (&lt;10 mL\/s). Two group B patients showed improved average flow rates posttreatment (p = 0.016); three in group A showed improvement but were not statistically significant (p = 0.197). Q max\/flow time ratio was abnormal in all group B patients pretreatment. Two of the nine improved posttreatment, while only one in group A did. Conclusions: Anticholinergic medications positively impact cystometric parameters and are effective for detrusor instability and low compliance bladder. \u03b1-Adrenergic blockers influence uroflow parameters and can help treat bladder outflow obstruction. Consideration for a larger study with extended follow-up is warranted. <\/jats:p>","DOI":"10.1159\/000541245","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T16:00:52Z","timestamp":1727971252000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the Role of Anticholinergics and \u03b1-1 Adrenergic Blockers in Bladder Management in Posterior Urethral Valves: A Pilot Randomized Control Trial"],"prefix":"10.1159","author":[{"given":"Ramyasree","family":"Bade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Kumar","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Kalavant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saswati","family":"Behera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palak","family":"Singhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)36638-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2003.04178.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.03.068"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2469-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.2692"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)36148-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00305-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000027507.32385.52"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2002.02881.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1201\/b13795-60"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_2554_20"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000029633.06239.b7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000135735.49099.8c"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/doi\/10.1159\/000541245\/4293477\/000541245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/doi\/10.1159\/000541245\/4293477\/000541245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:46Z","timestamp":1745422786000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1159\/000541245","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}