{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:25:06Z","timestamp":1745468706360,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Introduction: Cutaneous T-cell dyscrasia (CTCD) encompasses a heterogeneous group of T-cell infiltrates, often clonal and epitheliotropic. While the etiology remains unclear, certain medications, including statins, have been linked to cutaneous T-cell lymphocytic infiltrate development. Case Description: A patient presented with a pruritic, scaly eruption on her palms and soles unresponsive to topical steroids for 1 month. Histopathological examination revealed compact orthokeratosis, mild lymphocytic infiltrate with focal exocytosis, and atypical lymphocytes. Immunophenotyping demonstrated a predominance of CD3+ T cells with a 1:1 CD4\/CD8 ratio and reduced CD7 expression. The clinical presentation, histopathology, and immunophenotype supported a diagnosis of statin-induced CTCD. Conclusion: Statin discontinuation led to complete symptom resolution, emphasizing the reversibility of drug-induced T-cell dyscrasia. This case highlights the importance of a detailed medication history as drug-induced T-cell dyscrasia, unlike classic CTCD with its characteristic lymphoid atypia, phenotypic abnormalities, and clonality leading to a refractory course, can be reversed by drug withdrawal. <\/jats:p>","DOI":"10.1159\/000541258","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T16:00:36Z","timestamp":1729872036000},"page":"234-239","source":"Crossref","is-referenced-by-count":1,"title":["Keratoderma-Like T-Cell Dyscrasia: A Case Report"],"prefix":"10.1159","volume":"16","author":[{"given":"Asem","family":"Shadid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukaina","family":"Al Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rua\u2019a","family":"Alharithy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq J.","family":"Al-Zaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00969.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00938.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPBII68IJXUXHC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116342"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.029"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.181502"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(96)90365-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1561"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27740"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cde\/article-pdf\/16\/1\/234\/4293481\/000541258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cde\/article-pdf\/16\/1\/234\/4293481\/000541258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:57Z","timestamp":1745422797000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,6,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000541258","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.27178791","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"type":"electronic","value":"1662-6567"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}