{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:35:16Z","timestamp":1783571716652,"version":"3.55.0"},"reference-count":41,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Dis"],"abstract":"<jats:p>Introduction: Malignant hypertension (mHTN) is a hypertensive emergency. Thrombotic microangiopathy (TMA) is a widespread complication of mHTN. Few studies have evaluated whether glomerular hematuria provides prognostic information for renal dysfunction in patients with mHTN-associated TMA. Methods: This observational cohort study included 292 patients with mHTN-associated TMA based on renal biopsy. Propensity-score matching (PSM) analysis was conducted to adjust for clinical characteristics in a comparison between with and without glomerular hematuria. Cox regression was employed to identify risk factors for renal prognosis. Results: A total of 70 patients with glomerular hematuria were compared to 222 patients with non-glomerular hematuria. After PSM, 67 pairs of patients with mHTN-associated TMA were matched. Patients with glomerular hematuria exhibited lower serum albumin levels, higher 24-h proteinuria, and a higher prevalence of glomerular sclerosis than those with non-glomerular hematuria. Glomerular hematuria was independently associated with deteriorated renal function compared with non-glomerular hematuria (HR: 0.51; 95% CI: 0.29\u20130.89, p = 0.019). This association remained significant after PSM (HR: 0.51; 95% CI: 0.28\u20130.91, p = 0.022). Additionally, glomerular hematuria was independently associated with renal replacement therapy (RRT) (HR: 3.14; 95% CI: 2.06\u20135.66, p &lt; 0.001). This difference remained significant after PSM comparison (HR: 2.41; 95% CI: 1.34\u20134.33, p = 0.003). Furthermore, despite intensive blood pressure control, patients with glomerular hematuria experienced a higher incidence of RRT and a poorer recovery in renal function, specifically a 25% reduction of creatinine levels, compared to patients with non-glomerular hematuria. Conclusion: Glomerular hematuria is significantly associated with an increased risk of adverse renal outcomes in patients with mHTN-associated TMA. <\/jats:p>","DOI":"10.1159\/000541332","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T16:12:15Z","timestamp":1726157535000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["Glomerular Hematuria as a Predictor of Renal Prognosis in Malignant Hypertension Patients with Thrombotic Microangiopathy: A Propensity Score-Matched Analysis of a Biopsy-Based Cohort Study"],"prefix":"10.1159","author":[{"given":"Zhaocai","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyou","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01674-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001913"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvy032"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac248"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac324"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316669241"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0763-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017010108"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.09.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.479"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0777-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001134"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.3275"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.02.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000072"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn441217-20220630-00650"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.02.028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-022-01465-z"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.02.029"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003962.pub3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57305-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.012"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2018.06.005"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092205"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01207-7"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.842362"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104226"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04100321"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04910418"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.114"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac286"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000171"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn371"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.02.018"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001940"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00805-3"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121468"}],"container-title":["Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/kdd\/article-pdf\/doi\/10.1159\/000541332\/4289682\/000541332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/kdd\/article-pdf\/doi\/10.1159\/000541332\/4289682\/000541332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:40:42Z","timestamp":1745422842000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":41,"URL":"https:\/\/doi.org\/10.1159\/000541332","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.26984638","asserted-by":"subject"}]},"ISSN":["2296-9381","2296-9357"],"issn-type":[{"value":"2296-9381","type":"print"},{"value":"2296-9357","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]}}}