{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:12:04Z","timestamp":1790907124574,"version":"4.1.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"abstract":"<jats:p>Introduction: Platelets play parts in infection and immune processes. However, the association between platelet count and the risk of peritoneal dialysis (PD)-associated peritonitis is unclear. Methods: This was a retrospective, observational, single-center cohort study. A Cox regression analysis was used to evaluate the independent association of platelet count with the occurrence of first PD-associated peritonitis. Models were adjusted for gender, age, body mass index, cardiovascular disease, diabetes mellitus, white blood cell count, neutrophil-lymphocyte ratio, hemoglobin level, albumin level, potassium level, and anti-platelet medication usage. Results: A total of 2,374 patients were enrolled in this study (59% men; mean age 47.40 \u00b1 12.12). The average platelet count was 229.30 \u00b1 82.12 \u00d7 109\/L. 467 (20%) patients suffered from PD-associated peritonitis at least once. In the multivariable model, the adjusted hazard ratios (HRs) for quartiles 2, 3 and 4 versus quartile 1 were 1.428 (95% CI 1.060\u20131.924, p = 0.019), 1.663 (95% CI 1.240\u20132.229, p &lt; 0.001) and 1.843 (95% CI 1.363\u20132.492, p &lt; 0.001) with baseline data. A nonlinear relationship between platelet count and first PD-associated peritonitis was observed. Further, the association between platelet and first PD-associated peritonitis was significant in the patients with hypokalemia (P for interaction = 0.040). Conclusion: In PD patients, elevated platelet counts were significantly associated with an increased risk of the first onset of PD-associated peritonitis. <\/jats:p>","DOI":"10.1159\/000541567","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T16:00:35Z","timestamp":1727107235000},"page":"863-873","source":"Crossref","is-referenced-by-count":1,"title":["Higher Platelet Count Mostly in the Normal Range Is Associated with the First Episode of Peritonitis Risk in Incident Peritoneal Dialysis Patients"],"prefix":"10.1159","volume":"49","author":[{"given":"Jing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.05.032"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.02.025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.12.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0896860819879868"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00243"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00131"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2100152"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.11.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/483250"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/srep22964"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007252"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03495.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1458-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102355"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030314"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1246716"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1408-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00122"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500203"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1301-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01050211"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00452.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.02.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(03)00397-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.953129"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138999"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003682"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1181928"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-647362"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202672"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7911"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14188"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.9.2720"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.10.001"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00836.x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02385-2"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247518"}],"container-title":["Kidney 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