{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:25:24Z","timestamp":1758313524432,"version":"3.44.0"},"reference-count":45,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: The objective of this study was to assess the relationship between longitudinal changes in the uterine Doppler velocimetry and the maternal profile of angiogenic factors in the third trimester and to assess their ability to predict term preeclampsia (PE). Methods: A cohort of low-risk pregnant women was scheduled for a uterine Doppler evaluation and measurement of the circulating levels of angiogenic factors at \u223c30 and \u223c36 weeks. The performance of both parameters and their change over time in predicting term PE was evaluated. Results: A total of 1,191 women were analyzed, of which 28 (2.4%) women developed term PE. At \u223c30 weeks, a model including the sFlt-1\/PlGF (fms-like tyrosine kinase-1\/placental growth factor) ratio and the uterine Doppler explained 16.2% of the uncertainty of developing term PE, while at \u223c36 weeks, the same variables explained 25.2% [p &lt; 0.001]. The longitudinal changes of both predictors had an R2 of 26.8%, which was not different from that of the \u223c36 weeks evaluation [p = 0.45]. The area under the curve (AUC) of the \u223c36 weeks ratio was significantly higher than at \u223c30 weeks (0.86 [0.77\u20130.94] vs. 0.81 [0.73\u20130.9]; p = 0.043). The AUC of the longitudinal change of the ratio (0.85 [0.77\u20130.94]) did not differ from that of at \u223c36 weeks (p = 0.82). At \u223c36 weeks, for a 10% of false positives, the ratio had a detection rate of 71.4%. Conclusion: A cross-sectional measurement of the sFlt-1\/PlGF ratio outperforms uterine Doppler in predicting term PE. The combination of both markers does not improve such prediction, nor the evaluation of the longitudinal changes between weeks. <\/jats:p>","DOI":"10.1159\/000541731","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:01:01Z","timestamp":1730721661000},"page":"233-242","source":"Crossref","is-referenced-by-count":1,"title":["Added Value in Low-Risk Pregnancies of Longitudinal Changes in Uterine Doppler and Circulating Angiogenic Factors during the Third Trimester in Predicting Term Preeclampsia"],"prefix":"10.1159","volume":"52","author":[{"given":"Lucie","family":"Roubalova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimira","family":"Kroutilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Lopez-G. 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