{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:22:32Z","timestamp":1745468552159,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: According to guidelines, transrectal random biopsy of the prostate (TRBP) is performed under antibiotic prophylaxis (AP). Fosfomycin-trometamol (FOS) is not approved in Germany, but TRBP as indication was listed in the product information falsely. The aim was to investigate infectious complications of TRBP under FOS as a single dose. Methods: All TRBPs under FOS 3,000 mg as a single dose between July 1, 2020, and June 30, 2021, at a university institution were recorded. 357 patients (41\u201385 years old, median 66) were included. 243 received first TRBP, 321 TRBP were MRI-fusionated. 10\u201322 cores were taken (median 14). Prostate-specific antigen (PSA) was 0.1\u20131224 ng\/mL (median 7.7 ng\/mL), prostate volume 5\u2013263 mL (median 50 mL). Analysis was performed using Chi square test or Fisher\u2019s exact test, Mann-Whitney U test, and t test. Results: Four patients suffered an infection (1.1%), without significant difference according to age (p = 0.849), PSA (p = 0.957), number of cores (p = 0.905), and increase in volume (p = 0.456). Limiting is the retrospective character. Conclusion: The complication rate was 1.1%, and FOS single dose therefore represents sufficient AP for TRBP in this collective. FOS as a single dose should be reevaluated in a prospective study to obtain approval in Germany for this indication. <\/jats:p>","DOI":"10.1159\/000541798","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T16:01:03Z","timestamp":1727971263000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic Prophylaxis of Transrectal Biopsy of the Prostate: A Plea for Fosfomycin"],"prefix":"10.1159","author":[{"given":"Philipp Julian","family":"Spachmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Witt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Breyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Denzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Claudius","family":"Vergho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Julius","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59050911"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-018-0032-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2163-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/2090598x.2019.1592636"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2021.11.007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2018.11.020"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-023-01391-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.12.015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20220413"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.10.065"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000502851"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.06.014"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/doi\/10.1159\/000541798\/4297405\/000541798.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/doi\/10.1159\/000541798\/4297405\/000541798.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:53:45Z","timestamp":1745420025000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1159\/000541798","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}