{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:55:53Z","timestamp":1788389753309,"version":"build-2803163510"},"reference-count":39,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Exposure to cat allergens is often difficult to avoid. Here, we evaluated the safety and effectiveness of a depigmented, polymerized cat epithelium extract (Dpg-pol-cat) for the treatment of allergic rhinoconjunctivitis and asthma. Methods: Real-world, retrospective study of patients \u226512 years of age with cat allergy and moderate to severe allergic rhinitis\/rhinoconjunctivitis, with or without asthma, who started allergen immunotherapy (AIT) with Dpg-pol-cat extract during routine visits to the Allergy Department. Safety and effectiveness (improvement in FEV&lt;sub&gt;1&lt;\/sub&gt;) of AIT were evaluated. The use of rescue medication and patient perceptions were also assessed. Results: A total of 62 patients were included, of whom 34 (54.8%) received AIT for at least 12 months. There were 15 adverse events, 8 local and 7 systemic, of which 3 led to discontinuation of AIT. Patients with moderate to severe rhinitis decreased from 88.2% at baseline to 29.4% at 12 months (p &lt; 0.0001) and patients with moderate asthma decreased from 76.5% to 38.2% (p = 0.0004). FEV1 improved from a mean (standard deviation) of 3,188.9 (771.4) mL to 3,419.6 (878.4) mL (p = 0.0023). The use of rescue medication for rhinitis decreased from 94.1% to 23.5% (p &lt; 0.0001). All patients requiring rescue medication for conjunctivitis (20.6%) were off medication at 12 months, and 97.1% and 92.6% of patients reported improvement in rhinitis and asthma symptoms, respectively. Conclusion: AIT with Dpg-pol-cat extract shows a favorable safety and effectiveness profile in patients with allergic rhinitis\/rhinoconjunctivitis due to cat allergy, with or without allergic asthma, representing a valuable treatment option for these patients. <\/jats:p>","DOI":"10.1159\/000541838","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:00:50Z","timestamp":1731585650000},"page":"532-542","source":"Crossref","is-referenced-by-count":2,"title":["Depigmented, Polymerized Cat Epithelium Extract Is Safe and Improves Rhinitis and Asthma Symptoms in Cat-Allergic Patients: A Real-World Retrospective Study"],"prefix":"10.1159","volume":"186","author":[{"given":"Mar\u00eda","family":"V\u00e1zquez de la 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