{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:22:36Z","timestamp":1745468556216,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"abstract":"<jats:p>Introduction: We report a case of mantle cell lymphoma (MCL) with an apparent lineage switch to an EBV-positive T-cell lymphoma. Although lineage switch is a well-documented phenomenon in some hematolymphoid diseases, such as acute leukemias or histiocytic\/dendritic cell neoplasms, lineage switch from mature B-cell to T-cell lymphoma is exceedingly rare. Case Presentation: A 55-year-old man with an established history of MCL presented to our institution. Peripheral blood flow cytometry was consistent with MCL. Biopsy of a lumbar vertebral fracture site demonstrated MCL, EBV-associated, with large cells reminiscent of high-grade transformation (BCL1-positive). Two months later, a lymph node biopsy demonstrated an EBV-positive T-cell lymphoma without phenotypic evidence of B-cell lymphoma (BCL1-negative). Cytogenetic testing revealed CCND1::IGH fusion in all three specimens. IGH\/IGK clonality testing revealed conserved monoclonal peaks in all three samples; TCR clonality testing revealed monoclonal peaks in the T-cell lymphoma, only. NGS-based molecular genetic studies revealed shared mutations between the three samples, consistent with a clonal relationship suggesting evolution from MCL to T-cell lymphoma. Conclusions: This case demonstrates that lineage switch from mature B-cell to mature T-cell phenotype is possible in certain settings. Whether lineage switch in this case was potentiated by EBV infection is unclear. The loss of BCL1 expression in the T-cell lymphoma, despite conservation of the CCND1::IGH fusion, may be attributable to the downregulation of the IGH promoter as part of the shift from B-cell to T-cell phenotype. <\/jats:p>","DOI":"10.1159\/000541974","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:30:53Z","timestamp":1729056653000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Nodal T-Cell Lymphoma Transdifferentiated from Mantle Cell Lymphoma with Epstein-Barr Virus Infection"],"prefix":"10.1159","author":[{"given":"Paul D.","family":"Barone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Tam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia T.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu M.","family":"Ouseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13923"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqad035"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02691-w"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13038"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0197-CR"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/his.12009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001834"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1992.tb01951.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.933964"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916672556"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0104-RS"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/449410a"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01428-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124792"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nature06159"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-009-0031-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126054.95798.94"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pat\/article-pdf\/doi\/10.1159\/000541974\/4305988\/000541974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pat\/article-pdf\/doi\/10.1159\/000541974\/4305988\/000541974.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:55:19Z","timestamp":1745420119000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000541974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":20,"URL":"https:\/\/doi.org\/10.1159\/000541974","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}