{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:58:52Z","timestamp":1769003932946,"version":"3.49.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"<jats:p>Introduction: This study investigated the intraocular pressure (IOP) fluctuation as assessed by the water drinking test (WDT) in open-angle glaucoma (OAG) patients after combined cataract surgery with iStent implantation. Methods: This was a prospective non-randomized comparative study. Eyes with OAG and cataracts that were planned for either combined phacoemulsification and iStent implantation (iStent+CS) or phacoemulsification alone (CS) were recruited. The iStent inject (Model G2-M-IS) or iStent injectW (Model G2-W) trabecular micro-bypass stent (Glaukos Corporation, San Clemente, CA, USA) was implanted in the iStent+CS group. WDT was performed before and 3 months after surgery. WDT-IOP parameters including peak IOP, IOP fluctuation, and area under the curve (AUC) were compared between the two groups. Results: There were 20 eyes in the iStent+CS group and 16 eyes in the CS group. Both groups had similar pre-operative baseline IOP (15.6 \u00b1 3.7 mm Hg vs. 15.8 \u00b1 1.8 mm Hg in the iStent+CS and CS group, respectively, p = 0.883). The iStent+CS group experienced greater numerical reduction in peak IOP (2.6 \u00b1 1.9 mm Hg vs. 1.9 \u00b1 2.4 mm Hg; p = 0.355), IOP fluctuation (1.7 \u00b1 2.2 mm Hg vs. 0.8 \u00b1 2.5 mm Hg; p = 0.289), and AUC (54.8 \u00b1 103.6 mm Hg \u00d7 minute vs. 25.3 \u00b1 79.0 mm Hg \u00d7 minute; p = 0.355) than the CS group. There was more reduction in the number of anti-glaucoma medications in the iStent+CS group (1.4 \u00b1 1.2) than the CS group (0.3 \u00b1 0.9; p = 0.005). Conclusion: Both combined phacoemulsification with iStent inject implantation and phacoemulsification alone reduced peak IOP, IOP fluctuation, and AUC, and none of these parameters showed statistically significant difference. Greater reduction in anti-glaucoma medications was seen in the combined group. <\/jats:p>","DOI":"10.1159\/000542081","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T16:00:54Z","timestamp":1729267254000},"page":"635-643","source":"Crossref","is-referenced-by-count":2,"title":["Intraocular Pressure Fluctuation as Assessed by Water Drinking Test following iStent Inject Implantation in Open-Angle Glaucoma Patients"],"prefix":"10.1159","volume":"67","author":[{"given":"Phong Yue","family":"Khoo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenshen","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seng 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