{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:48:50Z","timestamp":1789753730339,"version":"4.0.1"},"reference-count":196,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Background: The novel coronavirus strain SARS-CoV-2 triggered the COVID-19 pandemic with severe economic and social ramifications. As the pathophysiology of SARS-CoV-2 infection in the respiratory system becomes more understood, growing evidence suggests that the virus also impacts the homeostasis-regulating neuroendocrine system, potentially affecting other organ systems. Summary: This review explores the interactions between SARS-CoV-2 and the neuroendocrine system, highlighting the effect of this virus on various endocrine glands, including the brain, hypothalamus, pituitary, pineal, thyroid, parathyroid, adrenal glands, pancreatic islets, gonads, and adipose tissue. The viral invasion disrupts normal hormonal pathways, leading to a range of endocrine disorders, immune dysregulation, and metabolic disturbances. Key Messages: There is potential for SARS-CoV-2 to induce autoimmune responses, exacerbate existing endocrine conditions, and trigger new-onset disorders. Understanding these interactions is crucial for developing treatment strategies that address not only the respiratory symptoms of COVID-19 but also its endocrine complications. The review emphasizes the need for further research to elucidate the long-term effects of SARS-CoV-2 on endocrine health. <\/jats:p>","DOI":"10.1159\/000542164","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T16:01:07Z","timestamp":1729526467000},"page":"1-18","source":"Crossref","is-referenced-by-count":3,"title":["SARS-CoV-2 Infection and the Neuroendocrine System"],"prefix":"10.1159","author":[{"given":"Shruti","family":"Sasikumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Unniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2008.05.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0273-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0406-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020361"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-009-0109-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-020-01311-x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.695"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901089R"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.146870"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1723055"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1293.2002.00114.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21896"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1099-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet1027"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2015.0020"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-010-9327-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.03.003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00643-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2196\/18810"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031716"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-138577"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00468-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111400119"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X221098970"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00459-7"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00679-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29145-3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.618891"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02697-y"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.09.009"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500877112"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00947-7"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20202135"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00915-1"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-024-01206-x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25728"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27024"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2020.10.010"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30287-X"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111406"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2021.04.013"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.5603\/PJNNS.a2022.0049"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25915"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101642"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.10.001"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1358873"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-03006-2"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191811497"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000284"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3390\/v13030498"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00012.2023"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00290-1"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00758-5"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00591-7"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1159\/000513040"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.5001\/OMJ.2021.128"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10091500"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab069"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323542"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1159\/000522115"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04381-9"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00265"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05542-y"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903060309"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00292.2006"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113784"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2021-1100"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab107"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.599255"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab045"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00859"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.02.008"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac312"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4281"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01486-0"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112855"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1177\/23247096211043386"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1177\/2329048x221103051"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13081210"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1177\/01455613231179714"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1042"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13315"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.06.004"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_305_2020"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105131"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.08.001"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041597"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10054-0145"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.32794\/mr11250079"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44010003"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12772"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2020-0371"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.3390\/diseases8040044"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001568"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4880"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00896-2"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1041676"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0363"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30266-7"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa830"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2022.18.1.58"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02770-6"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.aace.2020.12.005"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01366-7"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01440-0"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-021-00912-5"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221082898"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01436-w"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.3390\/life12040517"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa276"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0335"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02898-5"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100136"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0142"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2005.06.001"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1002\/path.1560"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10097"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac150.343"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11276"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-237690"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00700-8"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01276-8"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1055\/a-1191-8094"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2342-5"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009705"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00061.2021"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2017.10.010"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_440_20"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137326"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.593179"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1055\/a-1764-1260"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab349"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.3329\/BJMS.V20I5.55416"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01384-5"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-21-0144"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.11.012"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.04.040"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa108"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.678482"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.015"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.005"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23886-3"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00347-1"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.013"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.015"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-592374\/v1"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.1055\/a-1878-9566"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1318"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13733"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.3390\/life12091292"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1551"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.151551"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00348"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1980"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601896"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2015.01.018"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.1177\/20420188211010105"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.563893"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.3390\/endocrines3030046"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.22074\/cellj.2021.7982"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00261-z"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.15190\/d.2021.10"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1016\/j.sexol.2021.07.004"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1055\/a-1891-6621"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa030"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac107.432"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091431"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19020984"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.18565\/aig.2020.11.6-12"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj209078"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094472"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead093.811"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab182"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac037"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101013"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.12.022"},{"key":"ref183","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac105.055"},{"key":"ref184","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.05.025"},{"key":"ref185","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521001847"},{"key":"ref186","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.555039"},{"key":"ref187","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm9151"},{"key":"ref188","doi-asserted-by":"publisher","DOI":"10.3390\/life12101617"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020610"},{"key":"ref190","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3837640"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22867"},{"key":"ref192","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101783"},{"key":"ref193","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102154"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.813175"},{"key":"ref195","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S322831"},{"key":"ref196","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05389-0"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nen\/article-pdf\/doi\/10.1159\/000542164\/4300155\/000542164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nen\/article-pdf\/doi\/10.1159\/000542164\/4300155\/000542164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:03Z","timestamp":1745420223000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":196,"URL":"https:\/\/doi.org\/10.1159\/000542164","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}