{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:43:55Z","timestamp":1790793835166,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"abstract":"<jats:p>Introduction: Hydroxyapatite (HAP) is promoted as biomimetic material in dentistry. The aim of the study was to investigate whether HAP-containing formulations can reduce erosive\/abrasive tissue loss and to analyse components in these formulations. Methods: Two HAP toothpastes with and two without fluoride and a HAP mouthrinse were investigated, controls were active agent-free toothpaste, SnF&lt;sub&gt;2&lt;\/sub&gt; toothpaste and F\/Sn mouthrinse. For 10 days, human enamel samples were eroded for 2 min, 6\u00d7\/day in 0.5% citric acid and immersed for 2 min, 2\u00d7\/day in toothpaste slurries or mouthrinse. Half were additionally brushed for 15 s, 2\u00d7\/day. The particulate fraction was extracted and examined morphologically and with element analyses. Other parameters were REA, RDA, fluoride and calcium content. Results: The F\/Sn mouthrinse almost completely prevented tissue loss; none of the HAP formulations reduced tissue loss compared to the negative control, two increased it instead. Brushing increased tissue loss in all groups except the F\/Sn mouthrinse. All toothpastes contained amorphous particles of different sizes. Elemental analysis identified Si and O, and additionally, Ca and P were present in small amounts on the particles of the HAP toothpastes and one HAP+F toothpaste. In the liquid phase, elevated calcium levels were found in one HAP toothpaste and in both HAP+F toothpastes; in the formulation with the highest value, the fluoride concentration was low. REA and RDA values were not associated with tissue loss. Conclusions: Whether alone or in combination with fluoride, HAP formulations had either no or a detrimental effect on erosive tissue loss and could not reduce abrasion. In the context of erosive tooth wear, HAP seems to be neither an alternative to fluoride nor a suitable supplement to it. <\/jats:p>","DOI":"10.1159\/000542178","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T17:02:21Z","timestamp":1732640541000},"page":"139-150","source":"Crossref","is-referenced-by-count":7,"title":["Hydroxyapatite in Oral Care Products: In vitro Effects on Erosion\/Abrasion and Analysis of Formulation Components"],"prefix":"10.1159","volume":"59","author":[{"given":"Katja","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kerzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson T.","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Luka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schlueter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ganss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2022.105568"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2021.vol35.0114"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.873157"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.b2048359"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2196\/37519"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ma14174865"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.07.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53068"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ma15207173"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53790"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000334318"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.09.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38043-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/mawe.201100744"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80503-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.103247"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007868.pub3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics5020017"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2495\/dne-v9-n3-197-205"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S83642"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.24874\/ti.2018.40.03.11"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-021-06583-x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.201785"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21545-1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23146"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-020-2346-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000534057"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cre\/article-pdf\/59\/2\/139\/4304891\/000542178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cre\/article-pdf\/59\/2\/139\/4304891\/000542178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:09Z","timestamp":1745420229000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000542178","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}