{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:05:47Z","timestamp":1765487147875,"version":"3.40.4"},"reference-count":83,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: Previous studies reported inconsistent results of the association between Helicobacter pylori infection and nonalcoholic fatty liver disease (NAFLD). Methods: A cohort study of 2,063 adults without NAFLD at baseline, who participated in a repeated health checkup including a 13C-urea breath test and abdominal ultrasonography, was conducted to evaluate the link between H. pylori infection and NAFLD development. Results: During a mean follow-up period of 1.7 years, we did not find a significant association between H. pylori infection and NAFLD (hazard ratio = 1.10 (0.86, 1.40), p = 0.4689). We also found that higher age, body mass index (BMI), systolic blood pressure (systolic BP), diastolic blood pressure (diastolic BP), fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were risk factors, and high-density lipoprotein cholesterol (HDL-C) was a protective factor for NAFLD development. Conclusion: H. pylori infection might not be positively related to NAFLD development. <\/jats:p>","DOI":"10.1159\/000542180","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T17:00:21Z","timestamp":1730480421000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Helicobacter pylori Infection Is Not Associated with Nonalcoholic Fatty Liver Disease: A Two-Year Cohort Study"],"prefix":"10.1159","author":[{"given":"Huabo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangmeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengshuai","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songpu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/life12050718"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00003-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/ATV.0000000000000153"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.67"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40249"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.036"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221400"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.35.1.165"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114555"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2020.1810020"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20220319"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13520"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.711484"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.2.253"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1710945"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14319"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.10.015"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21280-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315363"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.50043.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00571.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69208-3"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.07.003"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12761"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.03.013"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042220-020814"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322368"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325630"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5016"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/life12111789"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210753"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307020"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30272-5"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00384-3"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01639-5"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10050904"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i21.6374"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i15.4750"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03011-w"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.012"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30429"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.09.039"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.025"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.22.07928-9"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9797841"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23746-0"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1337-y"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.06.007"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12646"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-021-00435-3"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12034"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1337-y"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12537"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00073"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02148-6"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41166-5"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221076975"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i17.5407"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.6.466"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.5.654"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-8-59"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221349"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.045"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13768"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2019.03.016"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-022-00868-3"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15220"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113863"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101238"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6073"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.10.018"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101092"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50032"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws448"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/doi\/10.1159\/000542180\/4312225\/000542180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/doi\/10.1159\/000542180\/4312225\/000542180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:57:10Z","timestamp":1745420230000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":83,"URL":"https:\/\/doi.org\/10.1159\/000542180","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.27434214","asserted-by":"subject"}]},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2024,11,1]]}}}