{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:22:50Z","timestamp":1745468570608,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>Objective: In this study, we have mapped the relative importance of well-defined recombinantly expressed Mycobacterium tuberculosis antigens in the T-cell recognition repertoire of latently infected individuals not progressing to active disease. Materials and Methods: Peripheral blood mononuclear cells from healthy latently infected long-term non-progressors were screened for antigen-induced proliferation and Th1 cytokine interferon-\u03b3 (IFN-\u03b3) responses. Results: The panel of antigens tested showed a clear spectrum of responsiveness and lead to the identification of a subgroup of frequently recognized antigens (MPT59, CFP7, CFP10, CFP21, TB37.6\/PPE68, ESAT-6, MPT51, and DnaK) with a high cellular response level as measured in both proliferation and IFN-\u03b3 assays. Among a subgroup of antigens also screened for responses in tuberculosis patients, CFP21 was identified as differentially recognized in non-progressors. For both cellular assays, we found a positive correlation between responder frequency and magnitude of response. A significant correlation between the level of antigen-specific proliferation and INF-\u03b3 secretion was also observed. Conclusion: We have identified a defined set of M. tuberculosis antigens frequently recognized by T cells at a high response level from latently infected long-term non-progressors which warrant further investigation for a potential role in immune regulation and protection against progression to active disease. <\/jats:p>","DOI":"10.1159\/000542324","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:03:28Z","timestamp":1730307808000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Relative Importance of Defined Mycobacterium tuberculosis Antigens in the T-Cell Recognition Repertoire of Latently Infected Individuals Not Progressing to Active Disease"],"prefix":"10.1159","author":[{"given":"Fredrik","family":"Oftung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Salim","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.11.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1508223"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0025-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0174-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.57-65.2005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00321"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.3933-3940.2000"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000084629"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.1.214-220.2000"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_232_20"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.10.5446-5453.2002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6116-6123.2003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103679"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9010027"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12723"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238586"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46252"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.051"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6332"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040652"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02452.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01235.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.6.2728-2735.1998"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2006.03.010"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5967-5971.1999"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6554-6557.2001"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-011-0188-z"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.07.007"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00103"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2019.04.012"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/mpp\/article-pdf\/doi\/10.1159\/000542324\/4306519\/000542324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/mpp\/article-pdf\/doi\/10.1159\/000542324\/4306519\/000542324.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:58:40Z","timestamp":1745420320000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1159\/000542324","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}